- ►diabetesjournals.org K Ozawa, M Miyazaki, M Matsuhisa, K Takano, … - Diabetes, 2005 - Am Diabetes Assoc To determine the role of the endoplasmic reticulum (ER) in diabetes, Akita mice,
a mouse model of type 2 diabetes, were mated with either heterozygous knockout
mice or two types of transgenic mice of 150-kDa oxygen-regulated protein ... Cited by 68 - Related articles - All 5 versions
- ►nih.gov YH Lee, S Nair, E Rousseau, DB Allison, GP … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Obesity increases the risk of developing major
diseases such as diabetes and cardiovas- cular disease. Adipose tissue,
particularly adipocytes, may play a major role in the development of ... Cited by 52 - Related articles - BL Direct - All 5 versions
- ►endojournals.org D Scheuner, RJ Kaufman - Endocrine Reviews, 2008 - Endocrine Soc The endoplasmic reticulum (ER) is the entry site into the secretory pathway for
newly synthesized proteins destined for the cell surface or released into the
extracellular milieu. The study of protein folding and trafficking within ... Cited by 38 - Related articles - BL Direct - All 5 versions
N Stefan, P Kovacs, M Stumvoll, RL Hanson, A … - Diabetes, 2003 - Am Diabetes Assoc Insulin receptor substrate (IRS)-2 plays an important role in insulin signaling
and its disruption results in diabetes in mice. In humans, the IRS-2 Gly1057Asp
substitution was associated with lower risk of type 2 diabetes in lean ... Cited by 37 - Related articles - BL Direct - All 4 versions
K Walder, D Segal, J Jowett, J Blangero, GR … - Current pharmaceutical design, 2003 - ingentaconnect.com Abstract: New treatments are currently required for the common metabolic
diseases obesity and type 2 diabetes. The identification of physiological and
biochemical factors that underlie the metabolic disturbances observed in ... Cited by 23 - Related articles - BL Direct - All 4 versions
H Yaguchi, K Togawa, M Moritani, M Itakura - Genomics, 2005 - Elsevier To identify new genetic determinants relevant to type 2 diabetes (T2D), diabetic
F2 progeny were generated by intercrossing F1 mice obtained from a cross of
BKS.Cg-Lepr db +/+m and DBA/2, and T2D-related phenotypes were measured. In ... Cited by 18 - Related articles - All 3 versions
PA Permana, A Del Parigi, PA Tataranni - Nutrition, 2004 - Elsevier Despite the remarkable advances in the understanding of the molecular biology
that may explain the etiology of obesity and its pathophysiologic consequences,
the exact cause of weight gain in the majority of people remains unknown, ... Cited by 9 - Related articles - All 6 versions
- ►hspsanddiabetes.com [PDF] PL Hooper - Metabolic syndrome and related disorders, 2007 - liebertonline.com Metabolic syndrome and type 2 diabetes are progressive, indolent, multi-organ
diseases. Un- derstanding the abnormalities of heat shock proteins (HSPs) in
these diseases is paramount to understanding their pathogenesis. In insulin ... Cited by 7 - Related articles - BL Direct - All 5 versions
GS Hotamisligil - Fatty Acid and Lipotoxicity in Obesity and Diabetes, 2007 - books.google.com Endoplasmic reticulum stress and inflammation in obesity and type 2 diabetes
Gokhan S. Hotamisligil Department of Genetics and Complex Diseases, Harvard
School of Public Health, Boston, MA 02115, USA Abstract. Metabolic and ... Cited by 6 - Related articles - BL Direct - All 4 versions
T Kobayashi, T Iguchi, Y Ohta - Comparative medicine, 2007 - aalas.org ORP150 is an endoplasmic-resident, hypoxic stress-induced protein, but little is
known about the effects of its systemic overex- pression. We have produced a
transgenic strain of mice that overexpress ORP150 (ORP-Tg mice). These mice ... Cited by 3 - Related articles - View as HTML - BL Direct - All 5 versions
