- ►ahajournals.org M Schupp, J Janke, R Clasen, T Unger, U Kintscher - Circulation, 2004 - Am Heart Assoc Methods and Results— The ARBs irbesartan and telmisartan (10 µmol/L) potently enhanced
PPAR -dependent 3T3-L1 adipocyte differentiation associated with a significant increase in mRNA
expression of the adipogenic marker gene adipose protein 2 (aP2), as measured by ... Cited by 441 - Related articles - BL Direct - All 7 versions
- ►ahajournals.org SC Benson, HA Pershadsingh, CI Ho, A Chittiboyina, P … - Hypertension, 2004 - Am Heart Assoc The metabolic syndrome is a common precursor of cardiovascular disease and type 2 diabetes
that is characterized by the clustering of insulin resistance, dyslipidemia, and increased blood
pressure. In humans, mutations in the peroxisome proliferator–activated receptor- (PPAR ... Cited by 432 - Related articles - BL Direct - All 10 versions
S Engeli, J Böhnke, M Feldpausch, K Gorzelniak, J … - Diabetes, 2005 - Am Diabetes Assoc Obesity is the main risk factor for the development of type 2 diabetes. Activation of the central
endocannabinoid system increases food intake and promotes weight gain. Blockade of the cannabinoid
type 1 (CB-1) receptor reduces body weight in animals by central and peripheral actions; ... Cited by 217 - Related articles - BL Direct - All 12 versions
- ►ahajournals.org AM Sharma, J Janke, K Gorzelniak, S Engeli, FC Luft - Hypertension, 2002 - Am Heart Assoc Obesity is the prime risk factor for the development of type 2 diabetes. Recent clinical trials have
shown that blockade of the renin-angiotensin system, either by inhibiting the angiotensin-converting
enzyme or blocking the angiotensin type 1 receptor, may substantially lower the risk for ... Cited by 216 - Related articles - BL Direct - All 8 versions
S Engeli, P Schling, K Gorzelniak, M Boschmann, J … - International Journal of …, 2003 - Elsevier Overfeeding of rodents leads to increased local formation of angiotensin II due to increased secretion
of angiotensinogen from adipocytes. Whereas angiotensin II promotes adipocyte growth and
preadipocyte recruitment, increased secretion of angiotensinogen from adipocytes also ... Cited by 172 - Related articles - All 4 versions
- ►alfediam.org [PDF] AJ Scheen - Diabetes and Metabolism, 2004 - Elsevier Most individuals with arterial hypertension or congestive heart failure are insulin-resistant and
at a higher risk of developing type 2 diabetes (T2DM). The inhibition of the renin-angiotensin
system (RAS), using an angiotensin converting enzyme inhibitor (ACEI) or a selective ... Cited by 160 - Related articles - All 6 versions
J Janke, S Engeli, M Boschmann, F Adams, J Böhnke, … - Diabetes, 2006 - Am Diabetes Assoc Studies in mice suggest that adipocytes serve as glucose sensors and regulate systemic glucose
metabolism through release of serum retinol-binding protein 4 (RBP4). This model has not been
validated in humans. RBP4 was highly expressed in isolated mature human adipocytes ... Cited by 146 - Related articles - BL Direct - All 6 versions
- ►shouxi.net M Schupp, M Clemenz, R Gineste, H Witt, J Janke, S … - Diabetes, 2005 - Am Diabetes Assoc Selective peroxisome proliferator–activated receptor (PPAR) γ modulation is a new pharmacological
approach that, based on selective receptor-cofactor interactions and target gene regulation, should
result in potent insulin sensitization in the absence of PPARγ-mediated adverse effects. ... Cited by 142 - Related articles - BL Direct - All 6 versions
- ►ypertasi.gr [PDF] TW Kurtz, M Pravenec - Journal of hypertension, 2004 - journals.lww.com Several lines of evidence suggest that angiotensin- converting enzyme (ACE) inhibitors and
some angiotensin II receptor blockers (ARBs) may improve insulin sensitivity and decrease the
risk for type 2 diabetes. It is widely assumed that the potential antidiabetic properties of ... Cited by 140 - Related articles - All 7 versions
K Gorzelniak, S Engeli, J Janke, FC Luft, AM … - Journal of …, 2002 - journals.lww.com Objective Adipose tissue secretes vasoactive substances which may contribute to the development
of obesity- related hypertension. The aim of this work was to study the expression of renin–angiotensin
system genes in adipose tissue of obese hypertensive subjects and the hormonal ... Cited by 126 - Related articles - BL Direct - All 6 versions
