P Newsholme, L Brennan, B Rubi, P Maechler - Clin. Sci, 2005 - cs.portlandpress.com Specific amino acids are now known to acutely and chronically regulate insulin secretion from
pancreatic β-cells in vivo and in vitro. Understanding the molecular mechanisms by which amino
acids regulate insulin secretion may identify novel targets for future diabetes therapies. ... Cited by 35 - Related articles - View as HTML - All 12 versions
- ►unige.ch [PDF] M Høy, P Maechler, AM Efanov, CB Wollheim, PO … - FEBS letters, 2002 - Elsevier Glutamate has been implicated as an intracellular messenger in the regulation of insulin secretion
in response to glucose. Here we demonstrate by measurements of cell capacitance in rat pancreatic
β-cells that glutamate (1 mM) enhanced Ca 2+ -dependent exocytosis. Glutamate (1 mM) ... Cited by 32 - Related articles - All 8 versions
- ►unige.ch [PDF] P Maechler, S Carobbio, B Rubi - International Journal of Biochemistry and Cell …, 2006 - Elsevier Pancreatic beta-cells are unique neuroendocrine cells displaying the peculiar feature of responding
to nutrients, principally glucose, as primary stimulus. This requires translation of a metabolic
substrate into intracellular messengers recognized by the exocytotic machinery. Central ... Cited by 29 - Related articles - All 7 versions
ML Yarmush, S Banta - Annual Review of Biomedical Engineering, 2003 - Annual Reviews ▪ Abstract The field of metabolic engineering encompasses a powerful set of tools that can be
divided into (a) methods to model complex metabolic pathways and (b) techniques to manipulate
these pathways for a desired metabolic outcome. These tools have recently seen ... Cited by 29 - Related articles - BL Direct - All 4 versions
- ►jbc.org B Rubi, A del Arco, C Bartley, J Satrustegui, P … - Journal of Biological …, 2004 - ASBMB The NADH shuttle system, which transports reducing equivalents from the cytosol to the
mitochondria, is essential for the coupling of glucose metabolism to insulin secretion in pancreatic
beta cells. Aralar1 and citrin are two isoforms of the mitochondrial aspartate/glutamate ... Cited by 29 - Related articles - All 6 versions
- ►unige.ch [PDF] C Broca, L Brennan, P Petit, P Newsholme, P Maechler - FEBS letters, 2003 - Elsevier In pancreatic β-cells, glutamate has been proposed to mediate insulin secretion as a
glucose-derived factor, although it is also considered for its sole catabolic function. Hence, changes
in cellular glutamate levels are a matter of debate. Here, we investigated the effects of ... Cited by 22 - Related articles - All 6 versions
G Dixon, J Nolan, NH McClenaghan, PR Flatt, P … - Clinical …, 2004 - cs.portlandpress.com Insulin-resistant states such as obesity can result in an increase in the function and mass of pancreatic
β-cells, so that insulin secretion is up-regulated and Type II diabetes does not develop.
However, expansion of β-cell mass is not indefinite and may well decrease with time. ... Cited by 18 - Related articles - View as HTML - BL Direct - All 11 versions
- ►physiology.org SB Haugaard, O Andersen, H Storgaard, F … - American Journal of …, 2004 - Am Physiological Soc We examined whether plasma concentrations of nonglucose insulin secretagogues are associated
with prehepatic insulin secretion rates (ISR) in nondiabetic, insulin-resistant, human immunodeficiency
virus (HIV)-infected, lipodystrophic patients (LIPO). Additionally, the negative feedback of ... Cited by 14 - Related articles - BL Direct - All 6 versions
SJ Yang, JW Huh, MJ Kim, WJ Lee, TU Kim, SY Choi, … - Biochimie, 2003 - Elsevier It has been known that glutamate, generated by glutamate dehydrogenase (GDH), acts as an
intracellular messenger in insulin exocytosis in pancreatic β cells. Here we demonstrate the correlation
of GDH activity and insulin release in rat pancreatic islets perfused with ... Cited by 14 - Related articles - All 5 versions
P Newsholme, K Bender, A Kiely, L … - Biochemical Society …, 2007 - ncbi.nlm.nih.gov In addition to the primary stimulus of glucose, specific amino acids may acutely and chronically
regulate insulin secretion from pancreatic beta-cells in vivo and in vitro. Mitochondrial metabolism
is crucial for the coupling of glucose, alanine, glutamine and glutamate recognition with ... Cited by 13 - Related articles - BL Direct - All 3 versions
