- ►nih.gov DK Hagman, LB Hays, SD Parazzoli, V … - Journal of Biological Chemistry, 2005 - ASBMB Abnormalities in lipid metabolism have been proposed as contributing factors to
both defective insulin secretion from the pancreatic beta cell and peripheral
insulin resistance in type 2 diabetes. Previously, we have shown that ... Cited by 42 - Related articles - BL Direct - All 10 versions
T Matsuda, K Omori, T Vuong, M Pascual, L … - American Journal of Transplantation, 2005 - interscience.wiley.com Nonspecific inflammation is associated with primary graft nonfunction (PNF).
Inflammatory islet damage is mediated at least partially by pro-inflammatory
cytokines, such as interleukin-1β (IL-1β) and tumor necrosis factor-α ... Cited by 39 - Related articles - All 4 versions
- ►diabetesjournals.org T Tabatabaie, A Vasquez-Weldon, DR Moore, … - Diabetes, 2003 - Am Diabetes Assoc Free radical formation evoked by proinflammatory cytokines has been suggested to
be involved in the destruction of β-cells in the course of type 1 diabetes
development. However, there is no direct evidence to support this ... Cited by 39 - Related articles - BL Direct - All 4 versions
RP Robertson, H Zhou, T Zhang, JS Harmon - Cell biochemistry and biophysics, 2007 - Springer Abstract Type 2 diabetes is characterized by a relentless decline in pancreatic
islet beta cell function and worsening hyperglycemia despite optimal medical
treatment. Our central hypothesis is that residual hyperglycemia, espe- ... Cited by 27 - Related articles - BL Direct - All 4 versions
KK Wu - Thrombosis research, 2003 - Elsevier Aspirin is an “old” drug with a number of new pharmacological actions. When
it was synthesized over a century ago based on the action of salicylate, it was
used in treating symptoms (fever and pain) associated with inflammation. ... Cited by 18 - Related articles - All 5 versions
- ►jbc.org MR Heitmeier, CB Kelly, NJ Ensor, KA Gibson, … - Journal of Biological Chemistry, 2004 - ASBMB Type I diabetes mellitus is an autoimmune disease characterized by the selective
destruction of the insulin-secreting -cell found in pancreatic islets of
Langerhans. Cytokines such as interleukin-1 (IL-1), interferon- (IFN- ), ... Cited by 17 - Related articles - All 4 versions
AK Andersson, L Thorvaldson, C Carlsson, S … - Molecular and cellular endocrinology, 2004 - Elsevier Cytokines may be involved in islet destruction during Type 1 diabetes. Exposure
to interleukin-1β (IL-1β) or IL-1β plus interferon-γ (IFN-γ) of rodent
islets induces expression of inducible nitric oxide synthase (iNOS) and ... Cited by 13 - Related articles - All 3 versions
- ►diabetesjournals.org SJ Persaud, D Muller, VD Belin, I Kitsou- … - Diabetes, 2007 - Am Diabetes Assoc The roles played by arachidonic acid and its cyclooxygenase (COX)-generated and
lipoxygenase (LOX)-generated metabolites have been studied using rodent islets
and insulin-secreting cell lines, but very little is known about COX and ... Cited by 12 - Related articles - BL Direct - All 5 versions
