I Ginis, Y Luo, T Miura, S Thies, R … - Developmental biology, 2004 - Elsevier We compared gene expression profiles of mouse and human ES cells by
immunocytochemistry, RT-PCR, and membrane-based focused cDNA array analysis.
Several markers that in concert could distinguish undifferentiated ES cells ... Cited by 347 - Related articles - All 4 versions
- ►nih.gov [PDF] S Georgia, A Bhushan - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig The endocrine pancreas undergoes major remodeling during neonatal development
when replication of differentiated β cells is the major mechanism by which β
cell mass is regulated. The molecular mechanisms that govern the ... Cited by 165 - Related articles - BL Direct - All 8 versions
- ►physiology.org L Bouwens, I Rooman - Physiological reviews, 2005 - Am Physiological Soc Beta-cell mass regulation represents a critical issue for understanding
diabetes, a disease characterized by a near-absolute (type 1) or relative (type
2) deficiency in the number of pancreatic beta cells. The number of islet ... Cited by 115 - Related articles - BL Direct - All 6 versions
J Buteau, W El-Assaad, CJ Rhodes, L … - Diabetologia, 2004 - Springer Aims/hypothesis. We have provided evidence that gluca- gon-like peptide-1, a
potential therapeutic agent in the treatment of diabetes, activates
phosphatidylinositol-3 kinase/protein kinase B signalling in the pancreatic ... Cited by 112 - Related articles - BL Direct - All 4 versions
DR Laybutt, M Glandt, G Xu, YB Ahn, N … - Journal of Biological Chemistry, 2003 - ASBMB We have proposed that hyperglycemia-induced dedifferentiation of -cells is a
critical factor for the loss of insulin secretory function in diabetes. Here we
examined the effects of the duration of hyperglycemia on gene expression in ... Cited by 68 - Related articles - BL Direct - All 4 versions
JJ Heit, ÅA Apelqvist, X Gu, MM Winslow, JR … - Nature, 2006 - nature.com The growth and function of organs such as pancreatic islets adapt to meet
physiological challenges and maintain metabolic balance, but the mechanisms
controlling these facultative responses are unclear 1, 2 . Diabetes in ... Cited by 68 - Related articles - BL Direct - All 6 versions
- ►sciencemag.org IC Rulifson, SK Karnik, PW Heiser, D ten … - Proceedings of the National Academy of Sciences, 2007 - National Acad Sciences There is widespread interest in defining factors and mechanisms that stimulate
proliferation of pancreatic islet cells. Wnt signaling is an important regulator
of organ growth and cell fates, and genes encoding Wnt-signaling factors ... Cited by 63 - Related articles - BL Direct - All 8 versions
- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by
the ß-cells of the pancreatic islet. Accordingly, strategies that lead to
increased pancreatic ß-cell mass, as well as retained or enhanced function ... Cited by 54 - Related articles - BL Direct - All 5 versions
L Soucek, ER Lawlor, D Soto, K Shchors, LB … - Nature medicine, 2007 - nature.com An association between inflammation and cancer has long been recognized, but the
cause and effect relationship linking the two remains unclear. Myc is a
pleiotropic transcription factor that is overexpressed in many human ... Cited by 50 - Related articles - BL Direct - All 4 versions
- ►nih.gov W Nishimura, T Kondo, T Salameh, I El … - Developmental biology, 2006 - Elsevier Major insulin gene transcription factors, such as PDX-1 or NeuroD1, have equally
important roles in pancreatic development and the differentiation of pancreatic
endocrine cells. Previously, we identified and cloned another critical ... Cited by 50 - Related articles - All 7 versions
