- ►daegu.ac.kr [PDF] E Kawasaki, N Abiru, K Eguchi - Diabetes research and clinical practice, 2004 - Elsevier The hallmark of immune-mediated type 1 diabetes is T cell-mediated destruction
of the insulin-producing β cells in the islets, which results from an imbalance
between disease promoting factors and protective elements. The precise ... Cited by 46 - Related articles - All 4 versions
O Micheau - ett, 2003 - Informa Pharma Science Cellular FLIP (c-FLIP), also known as FLICE-inhibitory protein, has been iden-
tified as an inhibitor of apoptosis triggered by engagement of death recep- tors
(DRs) such as Fas or TRAIL (TNF-related apoptosis-inducing ligand). c-FLIP ... Cited by 41 - Related articles - BL Direct - All 4 versions
H Hui, F Dotta, UD Mario, R Perfetti - Journal of cellular physiology, 2004 - interscience.wiley.com The homeostatic control of beta-cell mass in normal and pathological conditions
is based on the balance of proliferation, differentiation, and death of the
insulin-secreting cells. A considerable body of evidence, accumulated ... Cited by 42 - Related articles - BL Direct - All 4 versions
IA Urusova, L Farilla, H Hui, E D'Amico, R … - Trends in Endocrinology & Metabolism, 2004 - Elsevier Apoptosis plays an important role in the normal physiology of the pancreas, the
pathogenesis of diabetes mellitus (DM) and the success rate of islet
transplantation. Glucagon-like peptide-1 (GLP-1), an incretin hormone with ... Cited by 32 - Related articles - All 10 versions
- ►diabetesjournals.org JA Emamaullee, AM Shapiro - Diabetes, 2006 - Am Diabetes Assoc A substantial proportion of the transplanted islet mass fails to engraft due to
death by apoptosis, and a number of strategies have been explored to inhibit
β-cell loss. Inhibition of extrinsic signals of apoptosis (ie, cFLIP or ... Cited by 31 - Related articles - BL Direct - All 10 versions
- ►endojournals.org W Chen, KV Salojin, QS Mi, M Grattan, TC … - Endocrinology, 2004 - Endocrine Soc IGF-I regulates islet ß-cell growth, survival, and metabolism and protects
against type 1 diabetes (T1D). However, the therapeutic efficacy of free IGF-I
may be limited by its biological half-life in vivo. We investigated whether ... Cited by 30 - Related articles - BL Direct - All 4 versions
W Li, D Galey, MP Mattson, A Nath - Neurotoxicity Research, 2005 - Springer The deaths of neurons, astrocytes and endothe- lial cells have been described in
patients with HIV (human immunodeficiency virus) dementia. HIV-1 does not infect
neurons; instead, neurotoxic sub- stances shed by infected glia and ... Cited by 27 - Related articles - BL Direct - All 3 versions
CL Koski, S Hila, GE Hoffman - Endocrinology, 2004 - Endocrine Soc Mechanisms underlying the divergent effects of ovarian hormones on neuron death
induced by TNF were investigated in differentiated PC12 cells (dPC12). dPC12
cells were exposed to 17ß-estradiol (E, 1.0 nM), progesterone (P, 100 nM), ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►shouxi.net JA Emamaullee, RV Rajotte, P Liston, RG … - Diabetes, 2005 - Am Diabetes Assoc The Edmonton Protocol for treatment of type 1 diabetes requires islets from two
or more donors to achieve euglycemia in a single recipient, primarily because
soon after portal infusion, the majority of the transplanted cells undergo ... Cited by 24 - Related articles - BL Direct - All 8 versions
J Emamaullee, P Liston, RG Korneluk, AMJ … - Am J Transplant, 2005 - interscience.wiley.com Recent advances in clinical islet transplantation have allowed patients with
type 1 diabetes to become insulin independent, but the procedure is limited
since islets from two donors per recipient are typically required. This ... Cited by 21 - Related articles - All 5 versions
