GC Yaney, BE Corkey - Diabetologia, 2003 - Springer Increases in glucose or fatty acids affect metabolism via changes in long-chain acyl-CoA formation
and chronically elevated fatty acids increase total cellular CoA. Understanding the response
of pancreatic beta cells to increased amounts of fuel and the role that al- tered insulin ... Cited by 116 - Related articles - BL Direct - All 3 versions
SA Summers - Progress in Lipid Research, 2006 - Elsevier Obesity predisposes individuals to the development of insulin resistance in skeletal muscle and
the liver, and researchers have recently proposed two mechanisms by which excess adiposity
antagonizes insulin action in peripheral tissues. First, when adipocytes exceed their ... Cited by 114 - Related articles - All 3 versions
- ►ahajournals.org E Isganaitis, RH Lustig - Arteriosclerosis, thrombosis, and vascular …, 2005 - Am Heart Assoc Rates of obesity and insulin resistance have climbed sharply over the past 30 years. These epidemics
are temporally related to a dramatic rise in consumption of fast food; until recently, it was not
known whether the fast food was driving the obesity, or vice versa. We review the unique ... Cited by 47 - Related articles - All 13 versions
JH Moffitt, BA Fielding, R Evershed, R Berstan, JM … - Diabetologia, 2005 - Springer Abstract Aims/hypothesis: Long-term exposure of beta cells to lipids, particularly saturated fatty
acids in vitro, results in cellular dysfunction and apoptosis (lipotoxicity); this could contribute to
obesity-related diabetes. Our aims were to relate cell death to intracellular triglyceride ... Cited by 37 - Related articles - BL Direct - All 3 versions
- ►nutrition.org KV Axen, A Dikeakos, A Sclafani - Journal of Nutrition, 2003 - Am Soc Nutrition High fat, low carbohydrate diets are popularly advocated for weight loss and improvement in
metabolic Syndrome X, a constellation of risk factors for type 2 diabetes mellitus and cardiovascular
disease. The effects of an energy-restricted (to prevent weight gain in excess of normal ... Cited by 35 - Related articles - BL Direct - All 5 versions
- ►endojournals.org MJ Holness, GK Greenwood, ND Smith, MC Sugden - Endocrinology, 2003 - Endocrine Soc In healthy individuals, peripheral insulin resistance evoked by dietary saturated lipid can be accompanied
by increased insulin secretion such that glucose tolerance is maintained. Substitution of
long-chain -3 fatty acids for a small percentage of dietary saturated fat prevents insulin ... Cited by 28 - Related articles - BL Direct - All 4 versions
C Xiao, A Giacca, A Carpentier, GF Lewis - Diabetologia, 2006 - Springer Abstract Aims/hypothesis: Prolonged elevation of plas- ma specific fatty acids may exert differential
effects on glucose-stimulated insulin secretion (GSIS), insulin sensi- tivity and clearance. Subjects
and methods: We examined the effect of oral ingestion, at regular intervals for 24 h, of an ... Cited by 23 - Related articles - BL Direct - All 3 versions
F Assimacopoulos-Jeannet - International Journal of Obesity, 2004 - nature.com Obesity is associated with increased storage of lipids in nonadipose tissues like skeletal
muscle, liver, and pancreatic cells. These lipids constitute a continuous source of long-chain
fatty acyl CoA (LC-CoA) and derived metabolites like diacylglycerol and ceramide, acting ... Cited by 23 - Related articles - All 4 versions
- ►diabetesjournals.org AI Oprescu, G Bikopoulos, A Naassan, EM Allister, C … - Diabetes, 2007 - Am Diabetes Assoc RESULTS—Forty-eight–hour infusion of oleate decreased the insulin and C-peptide responses
to a hyperglycemic clamp (P < 0.01), an effect prevented by coinfusion of the antioxidants N-acetylcysteine
(NAC) and taurine. Similar to the findings in vivo, 48-h infusion of oleate decreased ... Cited by 21 - Related articles - BL Direct - All 3 versions
