- ►physiology.org MJ Dunne, KE Cosgrove, RM Shepherd, A … - Physiological …, 2004 - Am Physiological Soc The earliest description of hyperinsulinism appears to have been that provided by Laidlaw in
1938 who used the term nesidioblastosis to describe the severe, recurrent hypoglycemia associated
with an inappropriate elevation of serum insulin, C-peptide, and proinsulin (161). While ... Cited by 108 - Related articles - BL Direct - All 3 versions
GC Rodrigo, NB Standen - Current pharmaceutical design, 2005 - ingentaconnect.com INTRODUCTION Adenosine triphosphate-sensitive potassium channels (K ATP channels) were
discovered in the early 1980s in cardiac muscle and pancreatic β-cells [1-4], and have since
been identified in many other cells and tissues including skeletal muscle [5], neurons [6] ... Cited by 48 - Related articles - All 4 versions
J Bryan, WH Vila-Carriles, G Zhao, AP Babenko, L … - Diabetes, 2004 - Am Diabetes Assoc Advances in understanding the overall structural features of inward rectifiers and ATP-binding
cassette (ABC) transporters are providing novel insight into the architecture of ATP-sensitive
K + channels (K ATP channels) (K IR 6.0/SUR) 4 . The structure of the K IR pore has been ... Cited by 44 - Related articles - BL Direct - All 4 versions
J Bryan, A Crane, WH Vila-Carriles, AP … - Current …, 2005 - ingentaconnect.com Abstract: ATP-sensitive K + channels, termed K ATP channels, provide a link between cellular
metabolism and membrane electrical activity in a variety of tissues. Channel isoforms have been
identified and are targets for compounds that both stimulate and inhibit their activity ... Cited by 38 - Related articles - BL Direct - All 4 versions
- ►endojournals.org RA Ritzel, JB Hansen, JD Veldhuis, PC … - Journal of Clinical …, 2004 - Endocrine Soc In health, most insulin is secreted in pulses. Type 2 diabetes mellitus (TTDM) is characterized
by impaired pulsatile insulin secretion with a defect in insulin pulse mass. It has been suggested
that this defect is partly due to chronic overstimulation of ß-cells imposed by insulin ... Cited by 35 - Related articles - BL Direct - All 5 versions
C Moreau, AL Prost, R Dérand, M Vivaudou - Journal of molecular and cellular …, 2005 - Elsevier The sulfonylurea receptor SUR is an ATP binding cassette (ABC) protein of the ABCC/MRP
family. Unlike other ABC proteins, it has no intrinsic transport function, neither active nor
passive, but associates with the potassium channel proteins Kir6.1 or Kir6.2 to form the ... Cited by 36 - Related articles - All 6 versions
- ►nih.gov A Jahangir, A Terzic - Journal of molecular and cellular cardiology, 2005 - Elsevier The family of potassium channel openers regroups drugs that share the property of activating
adenosine triphosphate-sensitive potassium (K ATP ) channels, metabolic sensors responsible
for adjusting membrane potential-dependent functions to match cellular energetic ... Cited by 26 - Related articles - All 12 versions
JB Hansen, GA PO, TB Bodvarsdottir, P … - Current Medicinal …, 2004 - ingentaconnect.com Abstract: The pattern of insulin release is crucial for regulation of glucose and lipid
haemostasis. Deficient insulin release causes hyperglycemia and diabetes, whereas excessive
insulin release can give rise to serious metabolic disorders, such as nesidioblastosis ( ... Cited by 25 - Related articles - BL Direct - All 2 versions
AP Babenko - Journal of molecular and cellular cardiology, 2005 - Elsevier A multidisciplinary effort over twenty years has provided deep insight into the nature of K ATP
channels. First discovered in cardiomyocytes and pancreatic β-cells, as ubiquitous sensors of
the ADP/ATP ratio they are implicated in multiple disorders characterized by the ... Cited by 15 - Related articles - All 14 versions
KE Cosgrove, RM Shepherd, EM Fernandez, A … - Horm Res, 2004 - content.karger.com Hyperinsulinism in infancy (HI) is a condition of neonates and early childhood. For many years
the pathophysiology of this potentially lethal disorder was unknown. Advances in the
genetics, histopathology and molecular physiology of this disease have now provided ... Cited by 12 - Related articles - BL Direct - All 5 versions
