VK Mootha, CM Lindgren, KF Eriksson, A … - Nature genetics, 2003 - ws1.izbi.uni-leipzig.de Type 2 diabetes mellitus (DM2) affects over 110 million people world- wide and
is a principal contributor to atherosclerotic vascular disease, blindness,
amputation and kidney failure 1 . Defects in insulin secretion are observed ... Cited by 1298 - Related articles - BL Direct - All 24 versions
- ►pnas.org ME Patti, AJ Butte, S Crunkhorn, K Cusi, R … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Type 2 diabetes mellitus (DM) is characterized by insulin resistance and
pancreatic β cell dysfunction. In high-risk subjects, the earliest detectable
abnormality is insulin resistance in skeletal muscle. Impaired ... Cited by 667 - Related articles - BL Direct - All 15 versions
- ►nih.gov VK Mootha, C Handschin, D Arlow, X Xie, J St … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences Recent studies have shown that genes involved in oxidative phosphorylation
(OXPHOS) exhibit reduced expression in skeletal muscle of diabetic and
prediabetic humans. Moreover, these changes may be mediated by the ... Cited by 244 - Related articles - BL Direct - All 14 versions
- ►nih.gov K Morino, KF Petersen, S Dufour, D Befroy, J … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig To further explore the nature of the mitochondrial dysfunction and insulin
resistance that occur in the muscle of young, lean, normoglycemic,
insulin-resistant offspring of parents with type 2 diabetes (IR offspring), ... Cited by 165 - Related articles - BL Direct - All 10 versions
LM Sparks, H Xie, RA Koza, R Mynatt, MW … - Diabetes, 2005 - Am Diabetes Assoc Obesity and type 2 diabetes have been associated with a high-fat diet (HFD) and
reduced mitochondrial mass and function. We hypothesized a HFD may affect
expression of genes involved in mitochondrial function and biogenesis. To ... Cited by 155 - Related articles - All 5 versions
I Bogacka, H Xie, GA Bray, SR Smith - Diabetes, 2005 - Am Diabetes Assoc Thiazolidenediones such as pioglitazone improve insulin sensitivity in diabetic
patients by several mechanisms, including increased uptake and metabolism of
free fatty acids in adipose tissue. The purpose of the present study was to ... Cited by 122 - Related articles - All 5 versions
- ►cell.com JE Gunton, RN Kulkarni, SH Yim, T Okada, WJ … - Cell, 2005 - Elsevier Type 2 diabetes is an epidemic disease affecting almost 200 million people
worldwide (Zimmet et al., 2001). The pathogenesis involves two core defects:
insulin resistance and impaired β cell function ([Martin et al., 1992], ... Cited by 115 - Related articles - All 14 versions
K Højlund, K Wrzesinski, PM Larsen, SJ Fey, … - Journal of Biological Chemistry, 2003 - ASBMB Insulin resistance in skeletal muscle is a hallmark feature of type 2 diabetes.
An increasing number of enzymes and metabolic pathways have been implicated in
the development of insulin resistance. However, the primary cellular cause ... Cited by 94 - Related articles - BL Direct - All 5 versions
JR Wood, VL Nelson, C Ho, E Jansen, CY Wang … - Journal of Biological Chemistry, 2003 - ASBMB Page 1. 1 The Molecular Phenotype of Polycystic Ovary Syndrome (PCOS) Theca Cells
and New Candidate PCOS Genes Defined by Microarray Analysis ... Cited by 90 - Related articles - BL Direct - All 5 versions
Z Yan, S Choi, X Liu, M Zhang, JJ Schageman, … - Journal of Biological Chemistry, 2003 - ASBMB Mammalian skeletal muscles are capable of regeneration after injury. Quiescent
satellite cells are activated to reenter the cell cycle and to differentiate for
repair, recapitulating features of myogenesis during embryonic development. ... Cited by 83 - Related articles - BL Direct - All 10 versions
