- ►shouxi.net GS Eisenbarth, PA Gottlieb - The New England journal of medicine, 2004 - nejm.org Disease is determined by a subgroup of T cells that recognize one or more
peptides of the target organ. These peptides are bound in the groove of HLA
molecules and are presented to the T-cell receptor (TCR) of T lymphocytes. ... Cited by 192 - Related articles - BL Direct - All 16 versions
CC Goodnow, J Sprent, B Fazekas de St … - Nature, 2005 - direct-ms.org The mammalian immune system has an extraordinary potential for making receptors
that sense and neutralize any chemical entity entering the body. Inevitably,
some of these receptors recognize components of our own body, and so ... Cited by 183 - Related articles - View as HTML - All 7 versions
- ►coecxs.org [PDF] MT Ryan, NJ Hoogenraad, 2007 - Annual Reviews Abstract Mitochondria cannot be made de novo but replicate by a mechanism of
recruitment of new proteins, which are added to preexisting subcompartments.
Although mitochondria have their own DNA, more than 98% of the total ... Cited by 62 - Related articles - BL Direct - All 6 versions
- ►rupress.org X Chang, JX Gao, Q Jiang, J Wen, N Seifers, L … - Journal of Experimental Medicine, 2005 - jem.rupress.org The Scurfy mutation of the FoxP3 gene (FoxP3 sf ) in the mouse and analogous
mutations in human result in lethal autoimmunity. The mutation of FoxP3 in the
hematopoietic cells impairs the development of regulatory T cells. In ... Cited by 58 - Related articles - BL Direct - All 11 versions
G Morahan, L Morel - Current opinion in immunology, 2002 - Elsevier Why are some people better able to overcome infectious diseases than others? Why
is it that in some people these normally protective responses go awry so they
develop autoimmune diseases? Over the last two decades there have been ... Cited by 50 - Related articles - All 5 versions
S Onengut-Gumuscu, P Concannon - Immunological reviews, 2002 - interscience.wiley.com Summary: Type 1 diabetes (T1D) arises from autoimmune destruction of the β
cells of the pancreas leading to a complete dependence on exogenous insulin for
survival. Like many autoimmune disorders, the etiology of T1D is complex, ... Cited by 46 - Related articles - BL Direct - All 6 versions
- ►nih.gov M Pandarpurkar, L Wilson-Fritch, S Corvera, H … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences Apoptosis is a regulated cell death program controlled by extrinsic and
intrinsic signaling pathways. The intrinsic pathway involves stress signals that
activate pro-apoptotic members of the Bcl-2 family, inducing ... Cited by 48 - Related articles - BL Direct - All 11 versions
- ►nas.edu [PDF] JP Mordes, P Poussier, AR Rossini, EP … - Animal Models of Diabetes: Frontiers in Research - books.google.com 2 Animal Models of Diabetes BBDR Rats and Translational Modeling Fidelity 19
Immunological Perturbation and Diabetes Induction in Other Rat Strains 20
TLRLigation 20 Viral Infection 21 A Working Hypothesis of Autoimmune ... Cited by 43 - Related articles - BL Direct - All 4 versions
N van der Werf, FG Kroese, J Rozing, JL … - Diabetes/Metabolism Reviews - interscience.wiley.com During the last decades, the incidence of type 1 diabetes (T1D) has increased
significantly, reaching percentages of 3% annually worldwide. This increase
suggests that besides genetical factors environmental perturbations ... Cited by 39 - Related articles - BL Direct - All 3 versions
