- ►shouxi.net KF Petersen, S Dufour, D Befroy, R Garcia, … - The New England journal of medicine, 2004 - nejm.highwire.org Methods We performed hyperinsulinemic–euglycemic clamp studies in combination
with infusions of [6,6- 2 H 2 ]glucose in healthy, young, lean,
insulin-resistant offspring of patients with type 2 diabetes and insulin- ... Cited by 780 - Related articles - BL Direct - All 14 versions
- ►upmc.fr [PDF] KF Petersen, D Befroy, S Dufour, J Dziura, C … - Science, 2003 - sciencemag.org 420 article(s) on the ISI Web of Science. cited by This article has been ... :
subject collections This article appears in the following ... 2003 by the
American Association for the Advancement of Science; all rights reserved. ... Cited by 695 - Related articles - All 14 versions
- ►fafp.org [PDF] RA DeFronzo - Medical Clinics of North America, 2004 - Elsevier A discussion of the pathogenesis of type 2 diabetes mellitus must start with a
review of mechanisms involved in the maintenance of normal glucose homeostasis
in the basal or postabsorptive state (10–12 h overnight fast) and ... Cited by 692 - Related articles - BL Direct - All 5 versions
- ►harvard.edu [PDF] M Stumvoll, BJ Goldstein, TW van Haeften - The Lancet, 2005 - Elsevier Type 2 diabetes mellitus has become an epidemic, and virtually no physician is
without patients who have the disease. Whereas insulin insensitivity is an early
phenomenon partly related to obesity, pancreas β-cell function declines ... Cited by 431 - Related articles - All 17 versions
- ►nih.gov SE Shoelson, J Lee, AB Goldfine - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Over a hundred years ago, high doses of salicylates were shown to lower glucose
levels in diabetic patients. This should have been an important clue to link
inflammation to the pathogenesis of type 2 diabetes (T2D), but the ... Cited by 413 - Related articles - BL Direct - All 11 versions
- ►jbc.org VT Samuel, ZX Liu, X Qu, BD Elder, S Bilz, D … - Journal of Biological Chemistry, 2004 - ASBMB Short term high fat feeding in rats results specifically in hepatic fat
accumulation and provides a model of non-alcoholic fatty liver disease in which
to study the mechanism of hepatic insulin resistance. Short term fat ... Cited by 339 - Related articles - BL Direct - All 6 versions
- ►nih.gov H Shi, MV Kokoeva, K Inouye, I Tzameli, H Yin, … - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig TLR4 is the receptor for LPS and plays a critical role in innate immunity.
Stimulation of TLR4 activates proinflammatory pathways and induces cytokine
expression in a variety of cell types. Inflammatory pathways are activated ... Cited by 308 - Related articles - BL Direct - All 13 versions
- ►ahajournals.org J Kim, M Montagnani, KK Koh, MJ Quon - Circulation, 2006 - Am Heart Assoc Endothelial dysfunction contributes to cardiovascular diseases, including
hypertension, atherosclerosis, and coronary artery disease, which are also
characterized by insulin resistance. Insulin resistance is a hallmark of ... Cited by 312 - Related articles - All 9 versions
Z Gao, D Hwang, F Bataille, M Lefevre, D … - Journal of Biological Chemistry, 2002 - ASBMB Insulin resistance contributes importantly to the pathophysiology of type 2
diabetes mellitus. One mechanism mediating insulin resistance may involve the
phosphorylation of serine residues in insulin receptor substrate-1 (IRS-1), ... Cited by 293 - Related articles - BL Direct - All 5 versions
- ►endojournals.org H Bays, L Mandarino, RA DeFronzo - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance in liver
and muscle and impaired insulin secretion. Considerable evidence also implicates
deranged adipocyte metabolism and altered fat topography in the ... Cited by 242 - Related articles - All 4 versions
