- ►biologists.org H Wang, G Kouri, CB Wollheim - Journal of cell science, 2005 - jcs.biologists.org The reduction in insulin secretory capacity and ß-cell mass observed in type 2
diabetes is thought to be caused by glucolipotoxicity secondary to hyperglycemia
and hyperlipidemia. Our aim in this study was to elucidate the underlying ... Cited by 102 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org R Roduit, C Nolan, C Alarcon, P Moore, A … - Diabetes, 2004 - Am Diabetes Assoc The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin
secretion (GIIS) predicts that malonyl-CoA derived from glucose metabolism
inhibits fatty acid oxidation, thereby increasing the availability of ... Cited by 88 - Related articles - BL Direct - All 7 versions
YQ Liu, TL Jetton, JL Leahy - Journal of Biological Chemistry, 2002 - ASBMB The β-cell biochemical mechanisms that account for the compensatory
hyperfunction with insulin resistance (so-calledβ-cell adaptation) are unknown.
We investigated glucose metabolism in isolated islets from 10–12-week-old ... Cited by 63 - Related articles - BL Direct - All 4 versions
AM Efanov, S Sewing, K Bokvist, J Gromada - Diabetes, 2004 - Am Diabetes Assoc Liver X receptors (LXRs) α and β, transcription factors of a nuclear hormone
receptor family, are expressed in pancreatic islets as well as
glucagon-secreting and insulin-secreting cell lines. Culture of pancreatic ... Cited by 60 - Related articles - BL Direct - All 5 versions
- ►physiology.org MJ MacDonald, LA Fahien, LJ Brown, NM … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc The importance of mitochondrial biosynthesis in stimulus secretion coupling in
the insulin-producing -cell probably equals that of ATP production. In
glucose-induced insulin secretion, the rate of pyruvate carboxylation is ... Cited by 60 - Related articles - All 4 versions
- ►diabetesjournals.org F Schuit, D Flamez, A De Vos, D Pipeleers - Diabetes, 2002 - Am Diabetes Assoc The mammalian β-cell has particular properties that synthesize, store, and
secrete insulin in quantities that are matched to the physiological demands of
the organism. To achieve this task, β-cells are regulated both acutely and ... Cited by 55 - Related articles - BL Direct - All 5 versions
- ►nih.gov [PDF] F Diraison, L Parton, P Ferré, F Foufelle, CP … - Biochemical Journal, 2004 - pubmedcentral.nih.gov Accumulation of intracellular lipid by pancreatic islet β-cells has been
proposed to inhibit normal glucose-regulated insulin secretion
('glucolipotoxicity'). In the present study, we determine whether over- ... Cited by 54 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org CJ Nolan, MSR Madiraju, V Delghingaro- … - Diabetes, 2006 - Am Diabetes Assoc Fatty acids (FAs) and other lipid molecules are important for many cellular
functions, including vesicle exocytosis. For the pancreatic β-cell, while the
presence of some FAs is essential for glucose-stimulated insulin secretion, ... Cited by 54 - Related articles - BL Direct - All 5 versions
- ►cyclicamp.ca [PDF] D Delmeire, D Flamez, SA Hinke, JJ Cali, D … - Diabetologia, 2003 - Springer Aims/hypothesis. The secretory function of pancreatic beta cells is
synergistically stimulated by two signalling pathways which mediate the effects
of nutrients and hormones such as glucagon-like peptide 1 (GLP-1), glucose- ... Cited by 43 - Related articles - BL Direct - All 4 versions
S Gremlich, C Nolan, R Roduit, R Burcelin, … - Endocrinology, 2005 - Endocrine Soc The cellular response to fasting and starvation in tissues such as heart,
skeletal muscle, and liver requires peroxisome proliferator-activated receptor-
(PPAR )-dependent up-regulation of energy metabolism toward fatty acid ... Cited by 45 - Related articles - All 5 versions
