F Picard, M Kurtev, N Chung, A Topark-Ngarm, T … - Nature, 2004 - nature.com Calorie restriction extends lifespan in organisms ranging from yeast to mammals 1 . In yeast,
the SIR2 gene mediates the life-extending effects of calorie restriction 2 . Here we show that
the mammalian SIR2 orthologue, Sirt1 (sirtuin 1), activates a critical component of calorie ... Cited by 471 - Related articles - BL Direct - All 7 versions
- ►ahajournals.org M Schupp, J Janke, R Clasen, T Unger, U Kintscher - Circulation, 2004 - Am Heart Assoc Methods and Results— The ARBs irbesartan and telmisartan (10 µmol/L) potently enhanced
PPAR -dependent 3T3-L1 adipocyte differentiation associated with a significant increase in mRNA
expression of the adipogenic marker gene adipose protein 2 (aP2), as measured by ... Cited by 441 - Related articles - BL Direct - All 7 versions
- ►nih.gov H Kanda, S Tateya, Y Tamori, K Kotani, K … - Journal of Clinical …, 2006 - Am Soc Clin Investig Adipocytes secrete a variety of bioactive molecules that affect the insulin sensitivity of other
tissues. We now show that the abundance of monocyte chemoattractant protein–1 (MCP-1) mRNA
in adipose tissue and the plasma concentration of MCP-1 were increased both in ... Cited by 305 - Related articles - BL Direct - All 13 versions
H Ruan, HF Lodish - Cytokine and Growth Factor Reviews, 2003 - Elsevier Insulin resistance is a fundamental defect that precedes the development of the full insulin resistance
syndrome as well as β cell failure and type 2 diabetes. Tumor necrosis factor-α (TNF-α), a
paracrine/autocrine factor highly expressed in adipose tissues of obese animals and ... Cited by 240 - Related articles - All 10 versions
C Tiraby, G Tavernier, C Lefort, D Larrouy, F … - Journal of Biological …, 2003 - ASBMB Obesity, ie an excess of white adipose tissue (WAT), predisposes to the development of type
2 diabetes and cardiovascular disease. Brown adipose tissue is present in rodents but not in
adult humans. It expresses uncoupling protein 1 (UCP1) that allows dissipation of energy ... Cited by 171 - Related articles - BL Direct - All 5 versions
- ►endojournals.org C Knouff, J Auwerx - Endocrine Reviews, 2004 - Endocrine Soc The peroxisome proliferator-activated receptor (PPAR ) is a prototypical member of the nuclear
receptor superfamily and integrates the control of energy, lipid, and glucose homeostasis. PPAR
can bind a variety of small lipophilic compounds derived from metabolism and nutrition. ... Cited by 146 - Related articles - All 5 versions
- ►nih.gov JR Jones, C Barrick, KA Kim, J Lindner, B … - Proceedings of the …, 2005 - National Acad Sciences Peroxisome proliferator-activated receptor γ (PPARγ) plays a crucial role in adipocyte
differentiation, glucose metabolism, and other physiological processes. To further explore the
role of PPARγ in adipose tissues, we used a Cre/loxP strategy to generate ... Cited by 78 - Related articles - All 10 versions
- ►nih.gov AM Powelka, A Seth, JV Virbasius, E … - Journal of Clinical …, 2005 - Am Soc Clin Investig Using an siRNA-based screen, we identified the transcriptional corepressor RIP140 as a negative
regulator of insulin-responsive hexose uptake and oxidative metabolism in 3T3-L1
adipocytes. Affymetrix GeneChip profiling revealed that RIP140 depletion upregulates the ... Cited by 75 - Related articles - BL Direct - All 14 versions
- ►endojournals.org F Orio Jr, G Matarese, S Di Biase, S Palomba, D … - Journal of Clinical …, 2003 - Endocrine Soc Obesity affects about 44% of women with polycystic ovary syndrome (PCOS). Peroxisome
proliferator-activated receptor- (PPAR- ) is one of the genes involved in the differentiation of adipose
tissue. In an attempt to shed light on the high percentage of obesity in PCOS, we ... Cited by 62 - Related articles - BL Direct - All 4 versions
