- ►rockefeller.edu [PDF] JS Flier - Cell, 2004 - Elsevier The past ten years have been the golden age of obesity research. While long understood that
the amount of body weight and fat are determined by an interplay of inheritance and
environment, we are for the first time learning the identity of some of the responsible ... Cited by 498 - Related articles - All 27 versions
- ►shouxi.net PE Cryer - New England Journal of Medicine, 2004 - content.nejm.org In this article, I discuss the clinical problem of hypoglycemia in diabetes from the perspective
of pathophysiology. First, the syndromes of defective glucose counterregulation and hypoglycemia
without warning symptoms (known as "hypoglycemia unawareness") are described, ... Cited by 156 - Related articles - BL Direct - All 6 versions
GA Rutter, GDS Xavier, I Leclerc - Biochemical Journal, 2003 - pubmedcentral.nih.gov AMPK (5 -AMP-activated protein kinase) is emerging as a meta- bolic master switch, by which
cells in both mammals and lower organisms sense and decode changes in energy status. Changes
in AMPK activity have been shown to regulate glucose transport in muscle and glucose ... Cited by 141 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org R Wang, X Liu, ST Hentges, AA Dunn-Meynell, BE … - Diabetes, 2004 - Am Diabetes Assoc Glucosensing neurons in the hypothalamic arcuate nucleus (ARC) were studied using electrophysiological
and immunocytochemical techniques in neonatal male Sprague-Dawley rats. We identified
glucose-excited and -inhibited neurons, which increase and decrease, respectively, their ... Cited by 106 - Related articles - BL Direct - All 5 versions
- ►endojournals.org N Ibrahim, MA Bosch, JL Smart, J Qiu, M Rubinstein, … - Endocrinology, 2003 - Endocrine Soc Hypothalamic proopiomelanocortin (POMC) neurons are critical for controlling homeostatic functions
in the mammal. We used a transgenic mouse model in which the POMC neurons were labeled
with enhanced green fluorescent protein to perform visualized, whole-cell patch ... Cited by 106 - Related articles - BL Direct - All 5 versions
L Kang, VH Routh, EV Kuzhikandathil, LD Gaspers, BE … - Diabetes, 2004 - Am Diabetes Assoc To evaluate potential mechanisms for neuronal glucosensing, fura-2 Ca 2+ imaging and
single-cell RT-PCR were carried out in dissociated ventromedial hypothalamic nucleus
(VMN) neurons. Glucose-excited (GE) neurons increased and glucose-inhibited (GI) ... Cited by 94 - Related articles - BL Direct - All 7 versions
D Porte, DG Baskin, MW Schwartz - Diabetes, 2005 - Am Diabetes Assoc Insulin and its signaling systems are implicated in both central and peripheral mechanisms governing
the ingestion, distribution, metabolism, and storage of nutrients in organisms ranging from worms
to humans. Input from the environment regarding the availability and type of nutrients is ... Cited by 77 - Related articles - All 8 versions
- ►diabetesjournals.org ML Evans, RJ McCrimmon, DE Flanagan, T Keshavarz, … - Diabetes, 2004 - Am Diabetes Assoc It has been postulated that specialized glucose-sensing neurons in the ventromedial hypothalamus
(VMH) are able to detect falling blood glucose and trigger the release of counterregulatory hormones
during hypoglycemia. The molecular mechanisms used by glucose-sensing neurons are ... Cited by 74 - Related articles - BL Direct - All 5 versions
PE Cryer - Diabetes, 2005 - Am Diabetes Assoc Iatrogenic hypoglycemia is a problem for people with diabetes. It causes recurrent morbidity,
and sometimes death, as well as a vicious cycle of recurrent hypoglycemia, precluding maintenance
of euglycemia over a lifetime of diabetes. Improved therapeutic approaches that will ... Cited by 75 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org Z Song, VH Routh - Diabetes, 2005 - Am Diabetes Assoc Glucose directly alters the action potential frequency of glucosensing neurons in the ventromedial
hypothalamic nucleus (VMN). Glucose-excited neurons increase, and glucose-inhibited neurons
decrease, their action potential frequency as glucose increases from 0.1 to 2.5 mmol/l. ... Cited by 61 - Related articles - All 7 versions
