SB Jørgensen, B Viollet, F Andreelli, C Frøsig, JB … - Journal of Biological …, 2004 - ASBMB We investigated the importance of the two catalytic α-isoforms of the 5′-AMP-activated protein
kinase (AMPK) in 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) and
contraction-induced glucose uptake in skeletal muscle. Incubated soleus and EDL ... Cited by 190 - Related articles - BL Direct - All 4 versions
- ►nih.gov YC Long, JR Zierath - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig AMP-activated protein kinase (AMPK) is an energy sensor that regulates cellular
metabolism. When activated by a deficit in nutrient status, AMPK stimulates glucose uptake and
lipid oxidation to produce energy, while turning off energy-consuming processes ... Cited by 166 - Related articles - BL Direct - All 9 versions
- ►perioimplantelsalvador.com [PDF] BL Mealey, TW Oates - Journal of Periodontology, 2006 - Am Acad Periodontology Background: The purpose of this review is to provide the reader with practical knowledge concerning
the relationship between diabetes mellitus and periodontal diseases. Over 200 articles have
been published in the English literature over the past 50 years examining the relationship ... Cited by 160 - Related articles - BL Direct - All 18 versions
GA Rutter, GDS Xavier, I Leclerc - Biochemical Journal, 2003 - pubmedcentral.nih.gov AMPK (5 -AMP-activated protein kinase) is emerging as a meta- bolic master switch, by which
cells in both mammals and lower organisms sense and decode changes in energy status. Changes
in AMPK activity have been shown to regulate glucose transport in muscle and glucose ... Cited by 141 - Related articles - BL Direct - All 8 versions
MH Zou, SS Kirkpatrick, BJ Davis, JS Nelson, WG … - Journal of Biological …, 2004 - ASBMB Metformin, one of the most commonly used drugs for the treatment of type II diabetes, was recently
found to exert its therapeutic effects, at least in part, by activating the AMP-activated protein kinase
(AMPK). However, the site of its action, as well as the mechanism to activate AMPK, ... Cited by 127 - Related articles - BL Direct - All 7 versions
S Jäger, C Handschin, J St-Pierre, BM … - Proceedings of the …, 2007 - National Acad Sciences Activation of AMP-activated kinase (AMPK) in skeletal muscle increases glucose uptake, fatty
acid oxidation, and mitochondrial biogenesis by increasing gene expression in these
pathways. However, the transcriptional components that are directly targeted by AMPK ... Cited by 130 - Related articles - BL Direct - All 9 versions
- ►physiology.org A Barthel, D Schmoll - American Journal of Physiology- …, 2003 - Am Physiological Soc The regulation of hepatic gluconeogenesis is an important process in the adjustment of the blood
glucose level, and pathological changes in the glucose production of the liver are a central characteristic
in type 2 diabetes. The pharmacological intervention in signaling events that regulate the ... Cited by 123 - Related articles - BL Direct - All 3 versions
- ►endojournals.org NB Ruderman, AK Saha, EW Kraegen - Endocrinology, 2003 - Endocrine Soc An increasing body of evidence has linked AMP-activated protein kinase (AMPK) and malonyl
coenzyme A (CoA) to the regulation of energy balance. Thus, factors that activate AMPK and
decrease the concentration of malonyl CoA in peripheral tissues, such as exercise, ... Cited by 116 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org B Brunmair, K Staniek, F Gras, N Scharf, A Althaym, R … - Diabetes, 2004 - Am Diabetes Assoc Metformin and thiazolidinediones (TZDs) are believed to exert their antidiabetic effects via different
mechanisms. As evidence suggests that both impair cell respiration in vitro, this study compared
their effects on mitochondrial functions. The activity of complex I of the respiratory chain, ... Cited by 110 - Related articles - BL Direct - All 5 versions
- ►endojournals.org I Pavo, G Jermendy, TT Varkonyi, Z Kerenyi, A … - Journal of Clinical …, 2003 - Endocrine Soc Pioglitazone, a thiazolidinedione, improves glycemic control primarily by increasing peripheral
insulin sensitivity in patients with type 2 diabetes, whereas metformin, a biguanide, exerts its
effect primarily by decreasing hepatic glucose output. In the first head-to-head, ... Cited by 104 - Related articles - BL Direct - All 5 versions
