- ►case.edu [PDF] L Pirola, AM Johnston, EV Obberghen - Diabetologia, 2004 - Springer Insulin is a key hormone regulating the control of metabolism and the maintenance of normoglycaemia
and normolipidaemia. Insulin acts by binding to its cell surface receptor, thus activating the receptor's
intrinsic tyrosine kinase activity, resulting in receptor autophos- phorylation and ... Cited by 136 - Related articles - BL Direct - All 6 versions
- ►nih.gov A Tzatsos, KV Kandror - Molecular and cellular biology, 2006 - Am Soc Microbiol Nutritional excess and/or obesity represent well-known predisposition factors for the development
of non-insulin-dependent diabetes mellitus (NIDDM). However, molecular links between obesity
and NIDDM are only beginning to emerge. Here, we demonstrate that nutrients suppress ... Cited by 98 - Related articles - BL Direct - All 9 versions
- ►jbc.org R Somwar, S Koterski, G Sweeney, R Sciotti, S … - Journal of Biological …, 2002 - ASBMB Participation of p38 mitogen-activated protein kinase (p38) in insulin-induced glucose uptake
was suggested using pyridinylimidazole p38 inhibitors (eg SB203580). However, the role of
p38 in insulin action remains controversial. We further test p38 participation in glucose ... Cited by 74 - Related articles - BL Direct - All 4 versions
L Pirola, S Bonnafous, AM Johnston, C Chaussade, … - Journal of Biological …, 2003 - ASBMB Impaired glucose tolerance precedes type 2 diabetes and is characterized by
hyperinsulinemia, which develops to balance peripheral insulin resistance. To gain insight into
the deleterious effects of hyperinsulinemia on skeletal muscle, we studied the ... Cited by 67 - Related articles - BL Direct - All 3 versions
A Rudich, A Klip - Acta Physiologica Scandinavica, 2003 - interscience.wiley.com It is also possible that your web browser is not configured or not able to display style sheets.
In this case, although the visual presentation will be degraded, the site should continue to be
functional. We recommend using the latest version of Microsoft or Mozilla web browser to ... Cited by 61 - Related articles - BL Direct - All 4 versions
- ►jbc.org C Huang, ACP Thirone, X Huang, A Klip - Journal of Biological Chemistry, 2005 - ASBMB Insulin receptor substrates-1 and 2 (IRS-1 and IRS-2) are pivotal in relaying insulin signaling
in insulin-responsive tissues such as muscle. However, the precise contribution of IRS-1
vis-à-vis IRS-2 in insulin-mediated metabolic and mitogenic responses has not been ... Cited by 57 - Related articles - All 5 versions
A Rudich, D Konrad, D Török, R Ben-Romano, C … - Diabetologia, 2003 - Springer Aims/hypothesis. Insulin-dependent glucose influx in skeletal muscle and adipocytes is believed
to rely largely on GLUT4, but this has not been confirmed di- rectly. We assessed the relative
functional contribution of GLUT4 in experimental models of skeletal muscle and ... Cited by 56 - Related articles - BL Direct - All 3 versions
- ►nih.gov N Patel, A Rudich, ZA Khayat, R Garg, A … - Molecular and Cellular …, 2003 - Am Soc Microbiol Insulin stimulates glucose uptake by recruiting glucose transporter 4 (GLUT4) from an intracellular
pool to the cell surface through a mechanism that is dependent on phosphatidylinositol (PI)
3-kinase (PI3-K) and cortical actin remodeling. Here we test the hypothesis that insulin- ... Cited by 53 - Related articles - BL Direct - All 13 versions
- ►diabetesjournals.org XL Wang, L Zhang, K Youker, MX Zhang, J Wang, SA … - Diabetes, 2006 - Am Diabetes Assoc In metabolic syndrome, a systemic deregulation of the insulin pathway leads to a combined deregulation
of insulin-regulated metabolism and cardiovascular functions. Free fatty acids (FFAs), which
are increased in metabolic syndrome, inhibit insulin signaling and induce metabolic ... Cited by 49 - Related articles - BL Direct - All 4 versions
- ►physiology.org JLE Walgren, TS Vincent, KL Schey, … - American Journal of …, 2003 - Am Physiological Soc Increased flux through the hexosamine biosynthesis pathway has been implicated in the development
of glucose-induced insulin resistance and may promote the modification of certain proteins with
O-linked N-acetylglucosamine (O-GlcNAc). L6 myotubes (a model of skeletal muscle) ... Cited by 48 - Related articles - BL Direct - All 5 versions
