G Frühbeck - Biochemical Journal, 2006 - pubmedcentral.nih.gov Leptin is a versatile 16 kDa peptide hormone, with a tertiary structure resembling that of members
of the long-chain helical cytokine family. It is mainly produced by adipocytes in proportion to fat
size stores, and was originally thought to act only as a satiety factor. However, the ... Cited by 204 - Related articles - BL Direct - All 8 versions
- ►endojournals.org A Gavrila, CK Peng, JL Chan, JE Mietus, AL … - Journal of Clinical …, 2003 - Endocrine Soc Adiponectin is an abundant serum adipokine secreted exclusively from differentiated
adipocytes, which plays an important role in regulating insulin sensitivity. The dynamics of circulating
adiponectin concentrations have yet to be systematically investigated. We sought to ... Cited by 118 - Related articles - BL Direct - All 6 versions
- ►koki.hu [PDF] K Hegyi, K Fülöp, K Kovács, S Tóth, A Falus - Cell Biology International, 2004 - Elsevier Leptin is a multifunctional cytokine and hormone that primarily acts in the hypothalamus and
plays a key role in the regulation of food intake and energy expenditure. In addition, it has direct
effects on many cell types on the periphery. Leptin acts through its receptor, the product of ... Cited by 106 - Related articles - All 5 versions
IJ Hickman, EE Powell, JB Prins, AD Clouston, S Ash, … - Journal of hepatology, 2003 - Elsevier Results: Patients with viral genotype 3 had more severe steatosis (P=0.0001) and developed
stages 1 and 2 fibrosis at a younger age (P<0.05) than patients with genotype 1. For both
genotypes, overweight patients had significantly more steatosis and increased insulin ... Cited by 99 - Related articles - All 10 versions
C Garofalo, E Surmacz - Journal of cellular physiology, 2006 - interscience.wiley.com The prevalence of obesity has markedly increased over the past two decades, especially in the
industrialized countries. While the impact of excess body weight on the development of cardiac
disease and diabetes has been well documented, the link between obesity and ... Cited by 97 - Related articles - BL Direct - All 4 versions
H Ge, L Huang, T Pourbahrami, C Li - Journal of Biological Chemistry, 2002 - ASBMB Leptin is an adipocyte-derived hormone with potent effects on food intake and body weight. Genetically
obese rodents with mutations of leptin or leptin receptor develop morbid obesity and
diabetes. The receptor for leptin, OB-R, is alternatively spliced to at least five transcripts, ... Cited by 84 - Related articles - BL Direct - All 4 versions
P Stattin, R Palmqvist, S Söderberg, C Biessy, B Ardnor … - Oncology reports - ncbi.nlm.nih.gov Obesity is associated with an increased risk of colorectal cancer. Circulating levels of leptin are
high in obesity and strongly correlated to levels of insulin. Leptin stimulates growth of colon cancer
cells. In a nested case-control study, we measured leptin levels in prediagnostic plasma ... Cited by 71 - Related articles - BL Direct - All 4 versions
- ►endojournals.org G Yang, H Ge, A Boucher, X Yu, C Li - Molecular Endocrinology, 2004 - Endocrine Soc Soluble leptin receptor (SLR) represents the major leptin binding activity in plasma. It is generated
by alternative splicing of OB-R mRNA (OB-Re) and/or ectodomain shedding of membrane-spanning
receptors. To determine the role of SLR in leptin activation of its long-form receptor, ... Cited by 66 - Related articles - BL Direct - All 4 versions
- ►endojournals.org DR Mann, AOK Johnson, T Gimpel, VD … - Journal of Clinical …, 2003 - Endocrine Soc We determined developmental changes in circulating levels of the soluble leptin receptor
(sOB-R), leptin, and gonadal hormones in human subjects. In both sexes the rise in leptin with
age was associated with a decline in sOB-R, and age-related changes in both ... Cited by 59 - Related articles - BL Direct - All 4 versions
BE Wolfe, DC Jimerson, C Orlova, CS … - Clinical …, 2004 - phx1.medscape.com The goal of this study was to assess the extent to which a 4-week reduced-calorie diet in
healthy, normal-weight women is associated with alteration in circulating concentrations of
leptin, the soluble leptin binding protein (the short form of the leptin receptor, sOB-R), ... Cited by 59 - Related articles - BL Direct - All 9 versions
