BO Roep - Diabetologia, 2003 - Springer Type 1 diabetes mellitus results from a T-cell mediat- ed autoimmune destruction
of the pancreatic beta cells in genetically predisposed individuals. The
knowledge of the immunopathogenesis has increased enormously in the last ... Cited by 139 - Related articles - BL Direct - All 5 versions
- ►sediabetes.org [PDF] C Mathieu, C Gysemans, A Giulietti, R … - Diabetologia, 2005 - Springer Abstract Vitamin D deficiency predisposes individuals to type 1 and type 2
diabetes, and receptors for its activated form—1α,25-dihydroxyvitamin D 3
—have been identified in both beta cells and immune cells. Vitamin D ... Cited by 126 - Related articles - BL Direct - All 8 versions
E Etten, C Mathieu - Journal of Steroid Biochemistry and Molecular Biology, 2005 - Elsevier 1,25-Dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ), the biologically active metabolite
of Vitamin D 3 , not only regulates bone and calcium metabolism but also exerts
other biological activities, including immunomodulation via the nuclear ... Cited by 96 - Related articles - All 7 versions
L Adorini, N Giarratana, G Penna - Seminars in Immunology, 2004 - Elsevier Immunosuppressive and anti-inflammatory agents are able to generate tolerogenic
DCs, leading, in some cases, to induction or enhancement of regulatory T cells
with suppressive activity. This novel mechanism of action, shared by ... Cited by 87 - Related articles - All 2 versions
- ►voeljemens.nl [PDF] MD Griffin, N Xing, R Kumar - Annual review of nutrition, 2003 - Annual Reviews ▪ Abstract It has been a little more than 20 years since the first
appreciation that the biologically active hormonal form of the secosteroid
vitamin D—classically categorized as a regulator of calcium/phosphorous ... Cited by 86 - Related articles - BL Direct - All 6 versions
- ►direct-ms.org [PDF] C Mathieu, K Badenhoop - Trends in Endocrinology & Metabolism, 2005 - Elsevier Recent evidence suggests a role for vitamin D in pathogenesis and prevention of
diabetes mellitus. Active vitamin D, 1α,25(OH) 2 D 3 , prevents type 1 diabetes
in animal models, modifies T-cell differentiation, modulates dendritic cell ... Cited by 72 - Related articles - All 6 versions
- ►bloodjournal.org G Penna, A Roncari, S Amuchastegui, KC … - Blood, 2005 - Am Soc Hematology 1,25-dihydroxyvitamin D 3 (1,25(OH) 2 D 3 ) is a secosteroid hormone that
renders dendritic cells (DCs) tolerogenic, favoring the induction of regulatory
T cells. Induction of DCs with tolerogenic properties by 1,25(OH) 2 D 3 is ... Cited by 65 - Related articles - BL Direct - All 4 versions
- ►direct-ms.org [PDF] L Adorini - Cellular immunology, 2005 - Elsevier Vitamin D receptor (VDR) agonists are well known for their capacity to control
calcium metabolism and to regulate growth and differentiation of many cell
types. More recently, it has become clear that VDR agonists possess ... Cited by 56 - Related articles - All 5 versions
L Adorini, G Penna, N Giarratana, A Roncari, … - Journal of Steroid Biochemistry and Molecular Biology, 2004 - Elsevier Vitamin D receptor (VDR) ligands, in addition to controlling calcium metabolism,
exert important effects on the growth and differentiation of many cell types and
possess pronounced pro-tolerogenic immunoregulatory activities. VDR ligands ... Cited by 54 - Related articles - All 3 versions
- ►highwire.org AM Woltman, C van Kooten - Journal of leukocyte biology, 2003 - jleuk.highwire.org In recent years, dendritic cells (DCs) have entered the center court of immune
regulation. Dependent on their ontogeny, state of differentiation, and
maturation and thereby a variable expression of membrane-bound and soluble ... Cited by 52 - Related articles - BL Direct - All 5 versions
