- ►shouxi.net GS Eisenbarth, PA Gottlieb - The New England journal of medicine, 2004 - nejm.org Disease is determined by a subgroup of T cells that recognize one or more
peptides of the target organ. These peptides are bound in the groove of HLA
molecules and are presented to the T-cell receptor (TCR) of T lymphocytes. ... Cited by 192 - Related articles - BL Direct - All 16 versions
- ►nih.gov D Bresson, L Togher, E Rodrigo, Y Chen, JA … - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig Safe induction of autoantigen-specific long-term tolerance is the “holy
grail” for the treatment of autoimmune diseases. In animal models of type 1
diabetes, oral or in immunization with islet antigens induces Tregs that ... Cited by 91 - Related articles - BL Direct - All 12 versions
T Staeva-Vieira, M Peakman, M Von Herrath - Clinical and Experimental Immunology, 2007 - pubmedcentral.nih.gov Type 1 diabetes (T1D) is often considered the prototype organ-specific
autoimmune disease in clinical immunology circles. The key disease features −
precise destruction of a single endocrine cell type occurring on a distinct ... Cited by 47 - Related articles - BL Direct - All 5 versions
R Gianani, GS Eisenbarth - Immunological reviews, 2005 - interscience.wiley.com Summary: Type 1A diabetes is a chronic autoimmune disease usually preceded by a
long prodrome during which autoantibodies to islet autoantigens are present.
These antibodies are directed to a variety of antigens, but the best ... Cited by 42 - Related articles - All 4 versions
KS Goudy, R Tisch - International reviews of immunology, 2005 - informahealthcare.com A major effort has been on-going to develop immunotherapies to prevent and/or
treat type 1 diabetes (T1D). This autoimmune disease is characterized by the
selective loss of the insulin-producing β cells via the cumulative effects ... Cited by 25 - Related articles - BL Direct - All 5 versions
DG Alleva, RA Maki, AL Putnam, JM Robinson … - Scandinavian Journal of Immunology, 2006 - interscience.wiley.com NBI-6024 is an altered peptide ligand (APL) corresponding to the 9–23 amino
acid region of the insulin B chain (B (9−23) ), an epitope recognized by
inflammatory interferon-γ-producing T helper (Th)1 lymphocytes in type 1 ... Cited by 20 - Related articles - BL Direct - All 6 versions
- ►nih.gov D Bresson, M Von Herrath - Autoimmunity reviews, 2007 - Elsevier Every year, thirty thousand people worldwide are diagnosed with type 1 diabetes
mellitus (T1DM). T1DM, also called autoimmune diabetes, is a multifactorial
disease affecting predisposed individuals and involving genetic ... Cited by 20 - Related articles - All 3 versions
- ►jimmunol.org R Mukherjee, D Wagar, TA Stephens, E Lee- … - The Journal of Immunology, 2005 - Am Assoc Immnol Islet-specific glucose-6-phosphatase catalytic subunit-related protein (IGRP)
has been identified as a novel CD8 + T cell-specific autoantigen in NOD mice.
This study was undertaken to identify MHC class II-specific CD4 + T cell ... Cited by 16 - Related articles - All 6 versions
T Aly, D Devendra, GS Eisenbarth - American journal of therapeutics, 2005 - journals.lww.com Type 1A diabetes (T1D) is caused by autoimmune islet beta cell destruction
precipitated by environmental triggers in genetically predisposed individuals.
Islet beta cells produce insulin and are the primary target of this ... Cited by 15 - Related articles - BL Direct - All 3 versions
C Filippi, D Bresson, M Herrath - International reviews of immunology, 2005 - informahealthcare.com Since their discovery decades ago, regulatory T (Treg) cells have prompted many
investigations into their potential role in the generation or prevention of
autoimmune disorders such as type 1 diabetes (T1D). Initially identified ... Cited by 14 - Related articles - BL Direct - All 5 versions
