RS Jope, GVW Johnson - Trends in biochemical sciences, 2004 - Elsevier Glycogen synthase kinase-3 (GSK3) is now recognized as a key component of a
surprisingly large number of cellular processes and diseases. Several mechanisms
play a part in controlling the actions of GSK3, including phosphorylation, ... Cited by 492 - Related articles - All 5 versions
- ►sb-roscoff.fr [PDF] L Meijer, M Flajolet, P Greengard - Trends in pharmacological sciences, 2004 - Elsevier Three closely related forms of glycogen synthase kinase 3 (GSK-3α, GSK-3β and
GSK-3β2) have a major role in Wnt and Hedgehog signaling pathways and regulate
the cell-division cycle, stem-cell renewal and differentiation, apoptosis, ... Cited by 187 - Related articles - All 12 versions
DB Ring, KW Johnson, EJ Henriksen, JM Nuss … - Diabetes, 2003 - Am Diabetes Assoc Insulin resistance plays a central role in the development of type 2 diabetes,
but the precise defects in insulin action remain to be elucidated. Glycogen
synthase kinase 3 (GSK-3) can negatively regulate several aspects of ... Cited by 104 - Related articles - BL Direct - All 4 versions
TD Gould, JA Quiroz, J Singh, CA Zarate, HK … - Molecular psychiatry, 2004 - biozentrum.unibas.ch Bipolar disorder afflicts approximately 1–3% of both men and women, and is
coincident with major economic, societal, medical, and interpersonal
consequences. Current mediations used for its treatment are associated with ... Cited by 101 - Related articles - View as HTML - All 6 versions
JJ Trowbridge, A Xenocostas, RT Moon, M … - Nature medicine, 2006 - fhs.mcmaster.ca The in vivo regulation of hematopoietic stem cell (HSC) function is poorly
understood. Here, we show that hematopoietic repopulation can be augmented by
administration of a glycogen synthase kinase-3 (GSK-3) inhibitor to ... Cited by 92 - Related articles - BL Direct - All 7 versions
… AL Skaltsounis, V Myrianthopoulos, E Mikros … - Journal of medicinal chemistry, 2004 - sbr.sb-roscoff.fr Pharmacological inhibitors of glycogen synthase kinase-3 (GSK-3) and
cyclin-dependent kinases have a promising potential for applications against
several neurodegenerative diseases such as Alzheimer's disease. Indirubins, ... Cited by 90 - Related articles - View as HTML - BL Direct - All 11 versions
- ►cell.com MW Hulver, JR Berggren, MJ Carper, M … - Cell Metabolism, 2005 - Elsevier Obesity and type 2 diabetes are strongly associated with abnormal lipid
metabolism and accumulation of intramyocellular triacylglycerol, but the
underlying cause of these perturbations are yet unknown. Herein, we show ... Cited by 76 - Related articles - All 11 versions
AS Wagman, KW Johnson, DE Bussiere - Current pharmaceutical design, 2004 - ingentaconnect.com Abstract: Originally identified as a modulator of glycogen metabolism, glycogen
synthase kinase-3 (GSK3) is now understood to play an important regulatory role
in a variety of pathways including initiation of protein synthesis, cell ... Cited by 77 - Related articles - BL Direct - All 5 versions
PM Fischer - Current medicinal chemistry, 2004 - ingentaconnect.com Abstract: The human genome encompasses some 2,000 proteins that utilize
adenosine 5'-triphosphate (ATP) in one way or another and some 500 of these are
protein-tyrosine and protein-serine/threonine kinases (PTKs & PSTKs). ... Cited by 72 - Related articles - BL Direct - All 5 versions
- ►aspetjournals.org B Plotkin, O Kaidanovich, I Talior, H Eldar- … - Journal of Pharmacology and Experimental …, 2003 - ASPET Glycogen synthase kinase-3 (GSK-3) was shown to be a key factor in attenuation
of the cellular action of insulin. We speculated that inhibition of GSK-3 might
have a potential therapeutic value in treatment of insulin resistance and ... Cited by 63 - Related articles - BL Direct - All 4 versions
