- ►endojournals.org DG Hardie - Endocrinology, 2003 - Endocrine Soc All cells must maintain a high ratio of cellular ATP:ADP to survive. Because of the adenylate kinase
reaction (2ADP ATP + AMP), AMP rises whenever the ATP:ADP ratio falls, and a high cellular
ratio of AMP:ATP is a signal that the energy status of the cell is compromised. The AMP- ... Cited by 343 - Related articles - BL Direct - All 6 versions
- ►nih.gov JW Scott, SA Hawley, KA Green, M Anis, G … - Journal of Clinical …, 2004 - Am Soc Clin Investig CBS domains are defined as sequence motifs that occur in several different proteins in all kingdoms
of life. Although thought to be regulatory, their exact functions have been unknown.
However, their importance was underlined by findings that mutations in conserved ... Cited by 279 - Related articles - BL Direct - All 10 versions
- ►ahajournals.org MC Towler, DG Hardie - Circulation research, 2007 - Am Heart Assoc The AMP-activated protein kinase (AMPK) system acts as a sensor of cellular energy status that
is conserved in all eukaryotic cells. It is activated by increases in the cellular AMP:ATP ratio caused
by metabolic stresses that either interfere with ATP production (eg, deprivation for glucose ... Cited by 164 - Related articles - All 7 versions
GA Rutter, GDS Xavier, I Leclerc - Biochemical Journal, 2003 - pubmedcentral.nih.gov AMPK (5 -AMP-activated protein kinase) is emerging as a meta- bolic master switch, by which
cells in both mammals and lower organisms sense and decode changes in energy status. Changes
in AMPK activity have been shown to regulate glucose transport in muscle and glucose ... Cited by 141 - Related articles - BL Direct - All 8 versions
- ►endojournals.org NB Ruderman, AK Saha, EW Kraegen - Endocrinology, 2003 - Endocrine Soc An increasing body of evidence has linked AMP-activated protein kinase (AMPK) and malonyl
coenzyme A (CoA) to the regulation of energy balance. Thus, factors that activate AMPK and
decrease the concentration of malonyl CoA in peripheral tissues, such as exercise, ... Cited by 116 - Related articles - BL Direct - All 7 versions
- ►diabetesjournals.org B Brunmair, K Staniek, F Gras, N Scharf, A Althaym, R … - Diabetes, 2004 - Am Diabetes Assoc Metformin and thiazolidinediones (TZDs) are believed to exert their antidiabetic effects via different
mechanisms. As evidence suggests that both impair cell respiration in vitro, this study compared
their effects on mitochondrial functions. The activity of complex I of the respiratory chain, ... Cited by 110 - Related articles - BL Direct - All 5 versions
M Foretz, N Ancellin, F Andreelli, Y Saintillan, P … - Diabetes, 2005 - Am Diabetes Assoc AMP-activated protein kinase (AMPK) is a major therapeutic target for the treatment of
diabetes. We investigated the effect of a short-term overexpression of AMPK specifically in the
liver by adenovirus-mediated transfer of a gene encoding a constitutively active form of ... Cited by 102 - Related articles - All 5 versions
- ►physiology.org M Suwa, H Nakano, S Kumagai - Journal of Applied Physiology, 2003 - Am Physiological Soc This study was designed to determine the histological and metabolic effects of the administration
of 5'-AMP-activated protein kinase (AMPK) activator 5-aminoimidazole-4-carboxamide-1-
-D-ribofuranoside (AICAR) for 14 successive days. AICAR treatment caused a significant ... Cited by 92 - Related articles - BL Direct - All 5 versions
MJ Yoon, GY Lee, JJ Chung, YH Ahn, SH Hong, JB … - Diabetes, 2006 - Am Diabetes Assoc Adiponectin has recently received a great deal of attention due to its beneficial effects on insulin
resistance and metabolic disorders. One of the mechanisms through which adiponectin exerts
such effects involves an increase in fatty acid oxidation in muscle and liver. In the present ... Cited by 84 - Related articles - BL Direct - All 6 versions
DG HARDIE - Medicine & Science in Sports & Exercise, 2004 - journals.lww.com HARDIE, DG AMP-Activated Protein Kinase: A Key System Mediating Metabolic Responses
to Exercise. Med. Sci. Sports Exerc., Vol. 36, No. 1, pp. 28-34, 2004. The finding that AMP-activated
protein kinase (AMPK) was activated by exercise in skeletal muscle, reported by Winder ... Cited by 77 - Related articles - BL Direct - All 4 versions
