- ►nih.gov RK Semple, VKK Chatterjee, SO'Rahilly - Journal of Clinical Investigation, 2006 - Am Soc Clin Investig The nuclear receptor family of PPARs was named for the ability of the original
member to induce hepatic peroxisome proliferation in mice in response to
xenobiotic stimuli. However, studies on the action and structure of the 3 ... Cited by 237 - Related articles - BL Direct - All 10 versions
- ►endojournals.org C Knouff, J Auwerx - Endocrine Reviews, 2004 - Endocrine Soc The peroxisome proliferator-activated receptor (PPAR ) is a prototypical member
of the nuclear receptor superfamily and integrates the control of energy, lipid,
and glucose homeostasis. PPAR can bind a variety of small lipophilic ... Cited by 146 - Related articles - All 5 versions
M Gil-Campos, R Cañete, A Gil - Clinical Nutrition, 2004 - Elsevier Obesity and insulin resistance have been recognised as leading causes of major
health issues, particularly diabetes type 2 and metabolic syndrome. Although
obesity, defined as excess body fat, is frequently accompanied by insulin ... Cited by 134 - Related articles - All 10 versions
- ►endojournals.org M Gurnell, DB Savage, VKK Chatterjee, S O' … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc By the end of this decade, it has been estimated that between 200 million and
300 million people worldwide will meet World Health Organization diagnostic
criteria for diabetes mellitus. This epidemic of predominantly type 2 ... Cited by 129 - Related articles - BL Direct - All 5 versions
- ►upenn.edu [PDF] RR Banerjee, MA Lazar - Journal of Molecular Medicine, 2003 - Springer Insulin resistance, the inability of target tissues to re- spond normally to
insulin, is central to the pathophysiol- ogy of type 2 diabetes [1], but its
molecular basis re- mains poorly understood. Classically, the explanation ... Cited by 93 - Related articles - BL Direct - All 4 versions
JE Gerich - Mayo Clinic Proceedings, 2003 - mayoclinicproceedings.com From the Department of Medicine, University of Rochester School of Medicine and
Dentistry, Rochester, NY. Individual reprints of this article are not available.
Address corre- spondence to John E. Gerich, MD, Department of Medicine, ... Cited by 93 - Related articles - View as HTML - BL Direct - All 14 versions
- ►oxfordjournals.org A Memisoglu, FB Hu, SE Hankinson, JAE … - Human Molecular Genetics, 2003 - Oxford Univ Press The peroxisome proliferator-activated receptor (PPAR ) is a critical regulator
of adipogenesis. PPAR +/- mice are resistant to high-fat diet-induced obesity
and thus PPAR may mediate physiological responses to dietary fat in other ... Cited by 89 - Related articles - All 6 versions
S Schinner, WA Scherbaum, SR Bornstein, A … - Diabetic Medicine, 2005 - interscience.wiley.com Currently, we observe an epidemic expansion of diabetes mellitus. In subjects
with Type 2 diabetes the resistance of fat, muscle and liver to insulin is the
central pathophysiological event in the development of this disease. ... Cited by 71 - Related articles - All 5 versions
- ►diabetesjournals.org YL Muller, C Bogardus, BA Beamer, AR … - Diabetes, 2003 - Am Diabetes Assoc Obesity is a metabolic risk factor for type 2 diabetes, hypertension,
hyperlipidemia, and cardiovascular disease (1). The development of obesity
requires either an increasing number of differentiated adipocytes or an ... Cited by 64 - Related articles - BL Direct - All 4 versions
- ►endojournals.org F Orio Jr, G Matarese, S Di Biase, S Palomba, … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc Obesity affects about 44% of women with polycystic ovary syndrome (PCOS).
Peroxisome proliferator-activated receptor- (PPAR- ) is one of the genes
involved in the differentiation of adipose tissue. In an attempt to shed ... Cited by 62 - Related articles - BL Direct - All 4 versions
