DT Odom, N Zizlsperger, DB Gordon, GW Bell, NJ … - Science, 2004 - sciencemag.org The transcriptional regulatory networks that specify and maintain human tissue diversity are largely
uncharted. To gain insight into this circuitry, we used chromatin immunoprecipitation combined
with promoter microarrays to identify systematically the genes occupied by the ... Cited by 583 - Related articles - All 7 versions
JM Servitja, J Ferrer - Diabetologia, 2004 - Springer Transcription factors provide the genetic instructions that drive pancreatic development and enable
mature beta cells to function properly. To understand fully how this is accomplished, it is necessary
to unravel the regulatory networks formed by transcription fac- tors acting on their ... Cited by 107 - Related articles - BL Direct - All 4 versions
- ►oxfordjournals.org MI McCarthy - Human Molecular Genetics, 2004 - Oxford Univ Press The rapid increase in the prevalence of type 2 diabetes (T2D) represents a major challenge for
health care delivery worldwide. Identification of genes influencing individual susceptibility to
disease offers a route to better understanding of the molecular mechanisms underlying ... Cited by 94 - Related articles - All 4 versions
- ►diabetesjournals.org MN Weedon, KR Owen, B Shields, G Hitman, M Walker … - Diabetes, 2004 - Am Diabetes Assoc Hepatocyte nuclear factor (HNF)-4α is part of a transcription factor network that is key for the
development and function of the β-cell. Rare mutations in the HNF4α gene cause maturity-onset
diabetes of the young. A number of type 2 diabetes linkage studies have found evidence ... Cited by 85 - Related articles - BL Direct - All 5 versions
- ►endojournals.org T Vilsboll, FK Knop, T Krarup, A Johansen, S … - Journal of Clinical …, 2003 - Endocrine Soc The effect of the insulinotropic incretin hormone, glucagon-like peptide-1 (GLP-1), is preserved
in typical middle-aged, obese, insulin-resistant type 2 diabetic patients, whereas a defective
amplification of the so-called late-phase plasma insulin response (20–120 min) to ... Cited by 78 - Related articles - BL Direct - All 4 versions
- ►nih.gov RK Gupta, MZ Vatamaniuk, CS Lee, RC … - Journal of Clinical …, 2005 - Am Soc Clin Investig Mutations in the gene encoding hepatocyte nuclear factor-4α (HNF-4α) result in maturity-onset
diabetes of the young (MODY). To determine the contribution of HNF-4α to the maintenance
of glucose homeostasis by the β cell in vivo, we derived a conditional knockout of HNF-4α ... Cited by 75 - Related articles - All 7 versions
- ►oxfordjournals.org MA Maestro, SF Boj, RF Luco, CE Pierreux, J … - Human Molecular …, 2003 - Oxford Univ Press During pancreatic organogenesis endocrine cells arise from non self-renewing progenitors that
express Ngn3. The precursors that give rise to Ngn3 + cells are presumably located within
duct-like structures. However, the nature of such precursors is poorly understood. We ... Cited by 61 - Related articles - BL Direct - All 5 versions
- ►endojournals.org J Eeckhoute, E Moerman, T Bouckenooghe, B … - Endocrinology, 2003 - Endocrine Soc The nuclear receptor hepatocyte nuclear factor (HNF) 4 is involved in a transcriptional network
and plays an important role in pancreatic ß-cells. Mutations in the HNF4 gene are correlated
with maturity-onset diabetes of the young 1. HNF4 isoforms result from both alternative ... Cited by 58 - Related articles - BL Direct - All 3 versions
ER Pearson, SF Boj, AM Steele, T Barrett, K … - PLoS …, 2007 - medicine.plosjournals.org Macrosomia is associated with considerable neonatal and maternal morbidity. Factors that predict
macrosomia are poorly understood. The increased rate of macrosomia in the offspring of pregnant
women with diabetes and in congenital hyperinsulinaemia is mediated by increased ... Cited by 58 - Related articles - Cached - BL Direct - All 15 versions
ER Pearson, S Pruhova, CJ Tack, A Johansen, HAJ … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 878–885 DOI 10.1007/s00125-005-1738-y ARTICLE ER
Pearson . S. Pruhova . CJ Tack . A. Johansen . HAJ Castleden . PJ Lumb . AS Wierzbicki .
PM Clark . J. Lebl . O. Pedersen . S. Ellard . T. Hansen . AT Hattersley ... Cited by 57 - Related articles - All 5 versions
