JM Zabolotny, FG Haj, YB Kim, HJ Kim, GI Shulman … - Journal of Biological …, 2004 - ASBMB Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte
antigen-related phosphatase (LAR) as negative regulators of insulin signaling. The expression
and/or activity of PTP1B and LAR are increased in muscle of insulin-resistant rodents and ... Cited by 55 - Related articles - BL Direct - All 8 versions
- ►ebmonline.org RV Farese, MP Sajan, ML Standaert - Experimental Biology and Medicine, 2005 - SEBM Glucose transport into muscle is the initial process in glucose clearance and is uniformly defective
in insulin-resistant conditions of obesity, metabolic syndrome, and Type II diabetes mellitus. Insulin
regulates glucose transport by activating insulin receptor substrate-1 (IRS-1)–dependent ... Cited by 51 - Related articles - BL Direct - All 3 versions
LM Sly, MJ Rauh, J Kalesnikoff, T Büchse, G Krystal - Experimental hematology, 2003 - Elsevier The phosphatidylinositol-3 kinase (PI3K) pathway plays a central role in regulating numerous
biologic processes, including survival, adhesion, migration, metabolic activity, proliferation,
differentiation, and end cell activation through the generation of the potent second ... Cited by 48 - Related articles - All 9 versions
J Kalesnikoff, LM Sly, MR Hughes, T Büchse, MJ … - Reviews of Physiology, …, 2003 - Springer Rev Physiol Biochem Pharmacol (2003) 149:87–103 DOI 10.1007/s10254-003-0016-y ... J.
Kalesnikoff · LM Sly · MR Hughes · T. Büchse · MJ Rauh · L.-P. Cao · V. Lam · A. Mui · M. Huber
· G. Krystal ... The role of SHIP in cytokine-induced signaling ... Published online: 12 April ... Cited by 44 - Related articles - BL Direct - All 3 versions
T Sasaoka, T Wada, K Fukui, S Murakami, H … - Journal of Biological …, 2004 - ASBMB SH2-containing inositol phosphatase 2 (SHIP2) is a physiologically important negative regulator
of insulin signaling by hydrolyzing the phosphatidylinositol (PI) 3-kinase product PI 3,4,5-trisphosphate
in the target tissues of insulin. Targeted disruption of the SHIP2 gene in mice resulted in ... Cited by 41 - Related articles - BL Direct - All 4 versions
J ŽDYCHOVÁ, R Komers - Physiol. Res, 2005 - biomed.cas.cz Summary In addition to a number of deleterious effects on cellular integrity and functions, diabetic
metabolic milieu has been implicated in a rapidly growing number of alterations in signal
transduction. In this review we focus on Akt kinase physiology, its alterations in diabetes ... Cited by 43 - Related articles - View as HTML - All 5 versions
K Backers, D Blero, N Paternotte, J Zhang, C … - Advances in enzyme …, 2003 - ncbi.nlm.nih.gov 1: Adv Enzyme Regul. 2003;43:15-28. The termination of PI3K signalling by SHIP1
and SHIP2 inositol 5-phosphatases. Backers K, Blero D, Paternotte N, Zhang J, Erneux
C. Interdisciplinary Research Institute (IRIBHM), Université ... Cited by 41 - Related articles - All 3 versions
- ►physiology.org K Benkirane, F Amiri, QN Diep, M El … - American Journal of …, 2006 - Am Physiological Soc The present study evaluated the effects of peroxisome proliferator-activated receptor
(PPAR)- activators on ANG II-induced signaling pathways and cell growth. Vascular smooth muscle
cells (VSMC) derived from rat mesenteric arteries were treated with ANG II, with/without ... Cited by 38 - Related articles - BL Direct - All 3 versions
SA Smith - Biochimie, 2003 - Elsevier Insulin resistance is a key metabolic defect in type 2 diabetes that is exacerbated by obesity,
especially if the excess adiposity is located intra-abdominally/centrally. Insulin resistance underpins
many metabolic abnormalities—collectively known as the insulin resistance ... Cited by 35 - Related articles - All 5 versions
- ►physiology.org Y Ye, Y Lin, S Atar, MH Huang, JR Perez- … - American Journal of …, 2006 - Am Physiological Soc We assessed 1) whether pretreatment before ischemia with pioglitazone (Pio) limits infarct size
(IS) and whether this protective effect is due to nitric oxide synthase (NOS) and/or prostaglandin
production, as has been shown for atorvastatin (ATV); and 2) whether Pio and ATV have ... Cited by 35 - Related articles - BL Direct - All 3 versions
