- ►diabetesjournals.org RJ Gum, LL Gaede, SL Koterski, M Heindel, JE Clampit … - Diabetes, 2003 - Am Diabetes Assoc Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin receptor (IR) signal
transduction and a drug target for treatment of type 2 diabetes. Using PTP1B antisense oligonucleotides
(ASOs), effects of decreased PTP1B levels on insulin signaling in diabetic ob/ob mice ... Cited by 110 - Related articles - BL Direct - All 6 versions
- ►physiology.org E Asante-Appiah, BP Kennedy - American Journal of Physiology- …, 2003 - Am Physiological Soc Type 2 diabetes is increasing at an alarming rate worldwide, and there has been a considerable
effort in several laboratories to identify suitable targets for the design of drugs against the
disease. To this end, the protein tyrosine phosphatases that attenuate insulin signaling by ... Cited by 86 - Related articles - BL Direct - All 3 versions
- ►rupress.org T Matsuki, R Horai, K Sudo, Y Iwakura - Journal of Experimental …, 2003 - jem.rupress.org IL-1 is a proinflammatory cytokine that plays important roles in inflammation. However, the role
of this cytokine under physiological conditions is not known completely. In this paper, we analyzed
the role of IL-1 in maintaining body weight because IL-1 receptor antagonist–deficient (IL- ... Cited by 81 - Related articles - BL Direct - All 6 versions
JM Zabolotny, FG Haj, YB Kim, HJ Kim, GI Shulman … - Journal of Biological …, 2004 - ASBMB Previous studies implicate protein-tyrosine phosphatase 1B (PTP1B) and leukocyte
antigen-related phosphatase (LAR) as negative regulators of insulin signaling. The expression
and/or activity of PTP1B and LAR are increased in muscle of insulin-resistant rodents and ... Cited by 55 - Related articles - BL Direct - All 8 versions
M Zhu, J Miura, LX Lu, M Bernier, R DeCabo, MA … - Experimental gerontology, 2004 - Elsevier Caloric restriction (CR) has a well-known insulin sensitizing effect in vivo. Although this effect
has been confirmed in rodents and primates for many years, its precise molecular mechanisms
remain unknown. Here we show a significant increase in plasma adiponectin and a ... Cited by 50 - Related articles - All 4 versions
ZY Zhang, SY Lee - eid, 2003 - Informa Pharma Science Coordinated tyrosine phosphorylation is essential for signalling pathways regulated by insulin
and leptin. Type 2 diabetes and obesity are character- ised by resistance to hormones insulin
and leptin, possibly due to attenuated or diminished signalling from the receptors. ... Cited by 47 - Related articles - All 4 versions
- ►nih.gov S Galic, C Hauser, BB Kahn, FG Haj, BG Neel, … - Molecular and Cellular …, 2005 - Am Soc Microbiol The protein tyrosine phosphatase PTP1B is a negative regulator of insulin signaling and a therapeutic
target for type 2 diabetes. Our previous studies have shown that the closely related tyrosine phosphatase
TCPTP might also contribute to the regulation of insulin receptor (IR) signaling in vivo (S. ... Cited by 47 - Related articles - All 11 versions
- ►endojournals.org A Tups, C Ellis, KM Moar, TJ Logie, CL Adam, JG … - Endocrinology, 2004 - Endocrine Soc We present the first evidence that suppressor of cytokine signaling-3 (SOCS3), a protein inhibiting
Janus kinase/signal transducer and activator of transcription (STAT) signaling distal of the leptin
receptor, conveys seasonal changes in leptin sensitivity in the Siberian hamster. Food ... Cited by 44 - Related articles - BL Direct - All 8 versions
- ►endocrinology-journals.org IK Lund, JA Hansen, HS Andersen, NPH … - Journal of molecular …, 2005 - Soc Endocrinology Upon leptin binding, the leptin receptor is activated, leading to stimulation of the JAK/STAT signal
transduction cascade. The transient character of the tyrosine phosphorylation of JAK2 and STAT3
suggests the involvement of protein tyrosine phosphatases (PTPs) as negative regulators ... Cited by 38 - Related articles - All 10 versions
FG Haj, JM Zabolotny, YB Kim, BB Kahn, BG Neel - Journal of Biological …, 2005 - ASBMB Protein-tyrosine phosphatase 1B (PTP1B) is an important negative regulator of insulin and leptin
signaling in vivo. Mice lacking PTP1B (PTP1B–/– mice) are hyper-responsive to insulin and leptin
and resistant to diet-induced obesity. The tissue(s) that mediate these effects of global ... Cited by 38 - Related articles - All 9 versions
