- ►shouxi.net B Staels, JC Fruchart - Diabetes, 2005 - Am Diabetes Assoc Peroxisome proliferator–activated receptors (PPARs) play key roles in the
regulation of energy homeostasis and inflammation, and agonists of PPARα and
-γ are currently used therapeutically. Fibrates, first used in the 1970s ... Cited by 265 - Related articles - BL Direct - All 10 versions
- ►jbc.org O Gavrilova, M Haluzik, K Matsusue, JJ … - Journal of Biological Chemistry, 2003 - ASBMB Peroxisome proliferator-activated receptor (PPAR ) is a nuclear receptor that
mediates the antidiabetic effects of thiazolidinediones. PPAR is present in
adipose tissue and becomes elevated in fatty livers, but the roles of ... Cited by 221 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org J Tonelli, W Li, P Kishore, UB Pajvani, E … - Diabetes, 2004 - Am Diabetes Assoc Whereas thiazolidinediones (TZDs) are known to rapidly improve insulin action in
animals, short durations of TZD therapy have never been studied in humans. Among
the many known actions of TZDs, increased circulating levels of the high ... Cited by 142 - Related articles - BL Direct - All 5 versions
UB Pajvani, PE Scherer - Current Diabetes Reports, 2003 - Springer Introduction Adipose tissue, once consideredtobe irrelevant interms of its
endocrine potential, is now recognized as a critical mediator of a number of
physiologic processes, such as the innate immune response, vascular ... Cited by 130 - Related articles - BL Direct - All 3 versions
TM Larsen, S Toubro, A Astrup - International journal of obesity, 2003 - nature.com The nuclear hormone receptor peroxisome proliferator-activated receptor gamma
(PPAR ) is a member of the PPAR family. The endogenous activators of all members
of the PPAR family are a variety of fatty acids, which suggests that the ... Cited by 106 - Related articles - BL Direct - All 5 versions
- ►nih.gov G Jiang, Z Li, F Liu, K Ellsworth, Q Dallas- … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Effective therapies for the treatment of obesity, a key element of metabolic
syndrome, are urgently needed but currently lacking. Stearoyl-CoA desaturase–1
(SCD1) is the rate-limiting enzyme catalyzing the conversion of saturated ... Cited by 83 - Related articles - All 11 versions
RA Fuentealba, G Farias, J Scheu, M … - Brain Research Reviews, 2004 - Elsevier Alzheimer's disease (AD) is a neurodegenerative disorder with progressive
dementia accompanied by two main structural changes in the brain: intracellular
protein deposits termed neurofibrillary tangles (NFT) and extracellular ... Cited by 66 - Related articles - All 3 versions
A Szanto, V Narkar, Q Shen, IP Uray, PJA … - Cell Death & Differentiation, 2004 - nature.com Retinoid X receptor (RXR) belongs to a family of ligand-activated transcription
factors that regulate many aspects of metazoan life. A class of nuclear
receptors requires RXR as heterodimerization partner for their function. ... Cited by 61 - Related articles - All 4 versions
A Rubenstrunk, R Hanf, DW Hum, JC Fruchart, … - BBA-Molecular and Cell Biology of Lipids, 2007 - Elsevier Because of their wide range of actions on glucose homeostasis, lipid metabolism
and vascular inflammation, peroxisome proliferator-activated receptors (PPARs)
are promising targets for the development of new drugs for the treatment of ... Cited by 56 - Related articles - All 3 versions
A Hammarstedt, CX Andersson, V Rotter … - Prostaglandins, Leukotrienes & Essential Fatty Acids, 2005 - Elsevier Insulin resistance is frequently accompanied by obesity and both obesity and
type 2 diabetes are associated with a mild chronic inflammation. Elevated levels
of various cytokines, such as TNF-α and IL-6, are typically found in the ... Cited by 48 - Related articles - All 6 versions
