- ►cell.com BB Kahn, T Alquier, D Carling, DG Hardie - Cell metabolism, 2005 - Elsevier The AMP-activated protein kinase (AMPK) is an evolutionarily conserved sensor of
cellular energy status, and recent data demonstrate that it also plays a
critical role in systemic energy balance. AMPK integrates nutritional and ... Cited by 641 - Related articles - All 11 versions
SA Hawley, J Boudeau, JL Reid, KJ Mustard, L … - Journal of biology, 2003 - jbiol.com The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy
charge that acts as a 'metabolic master switch' and inhibits cell proliferation.
Activation requires phosphorylation of Thr172 of AMPK within the activation ... Cited by 460 - Related articles - Cached - All 13 versions
- ►daegu.ac.kr [PDF] D Carling - Trends in biochemical sciences, 2004 - Elsevier AMP-activated protein kinase (AMPK) is the downstream component of a protein
kinase cascade that acts as an intracellular energy sensor maintaining the
energy balance within the cell. This pivotal role of AMPK places it in an ... Cited by 376 - Related articles - All 12 versions
- ►biologists.org DG Hardie - Journal of cell science, 2004 - jcs.biologists.org The AMP-activated protein kinase (AMPK) cascade is a sensor of cellular energy
status. Whenever the cellular ATP:ADP ratio falls, owing to a stress that
inhibits ATP production or increases ATP consumption, this is amplified by ... Cited by 346 - Related articles - BL Direct - All 12 versions
- ►endojournals.org DG Hardie - Endocrinology, 2003 - Endocrine Soc All cells must maintain a high ratio of cellular ATP:ADP to survive. Because of
the adenylate kinase reaction (2ADP ATP + AMP), AMP rises whenever the ATP:ADP
ratio falls, and a high cellular ratio of AMP:ATP is a signal that the ... Cited by 341 - Related articles - BL Direct - All 6 versions
SA Hawley, DA Pan, KJ Mustard, L Ross, J … - Cell metabolism, 2005 - Elsevier The AMP-activated protein kinase (AMPK) is a critical regulator of energy
balance at both the cellular and whole-body levels. Two upstream kinases have
been reported to activate AMPK in cell-free assays, ie, the tumor ... Cited by 303 - Related articles - All 4 versions
- ►nih.gov JW Scott, SA Hawley, KA Green, M Anis, G … - Journal of Clinical Investigation, 2004 - Am Soc Clin Investig CBS domains are defined as sequence motifs that occur in several different
proteins in all kingdoms of life. Although thought to be regulatory, their exact
functions have been unknown. However, their importance was underlined by ... Cited by 279 - Related articles - BL Direct - All 10 versions
M Tiikkainen, AM Häkkinen, E Korsheninnikova … - Diabetes, 2004 - Am Diabetes Assoc Both rosiglitazone and metformin increase hepatic insulin sensitivity, but their
mechanism of action has not been compared in humans. The objective of this study
was to compare the effects of rosiglitazone and metformin treatment on ... Cited by 276 - Related articles - BL Direct - All 6 versions
DG Hardie, JW Scott, DA Pan, ER Hudson - FEBS letters, 2003 - Elsevier The AMP-activated protein kinase is a sensor of cellular energy status that is
found in all eukaryotic cells. It is activated by rising AMP and falling ATP by
a complex mechanism that results in an ultrasensitive response. The ... Cited by 267 - Related articles - All 11 versions
U Andersson, K Filipsson, CR Abbott, A Woods … - Journal of Biological Chemistry, 2004 - ASBMB AMP-activated protein kinase (AMPK) is the downstream component of a protein
kinase cascade that acts as an intracellular energy sensor maintaining the
energy balance within the cell. The finding that leptin and adiponectin ... Cited by 267 - Related articles - BL Direct - All 14 versions
