- ►endojournals.org JW Tomlinson, EA Walker, IJ Bujalska, N … - Endocrine Reviews, 2004 - Endocrine Soc 11ß-Hydroxysteroid dehydrogenase type 1 (11ß-HSD1) interconverts inactive
cortisone and active cortisol. Although bidirectional, in vivo it is believed to
function as a reductase generating active glucocorticoid at a prereceptor ... Cited by 251 - Related articles - BL Direct - All 4 versions
- ►nih.gov BA Laffitte, LC Chao, J Li, R Walczak, S … - Proceedings of the National Academy of Sciences of …, 2003 - National Acad Sciences The control of lipid and glucose metabolism is closely linked. The nuclear
receptors liver X receptor (LXR)α and LXRβ have been implicated in gene
expression linked to lipid homeostasis; however, their role in glucose ... Cited by 226 - Related articles - BL Direct - All 10 versions
- ►nih.gov JM Paterson, NM Morton, C Fievet, CJ Kenyon, … - Proceedings of the National Academy of Sciences, 2004 - National Acad Sciences In obese humans and rodents there is increased expression of the key
glucocorticoid (GC) regenerating enzyme, 11β-hydroxysteroid dehydrogenase type
1 (11β-HSD1), in adipose tissue. This increased expression appears to be ... Cited by 144 - Related articles - BL Direct - All 10 versions
KR Steffensen, JÅ Gustafsson - Diabetes, 2004 - Am Diabetes Assoc The nuclear receptors liver X receptor (LXR)α and LXRβ are sensors of
cholesterol metabolism and lipid biosynthesis. They have recently been found to
be regulators of inflammatory cytokines, suppressors of hepatic glucose ... Cited by 107 - Related articles - BL Direct - All 4 versions
JR Seckl, NM Morton, KE Chapman, BR … - Recent progress in hormone research, 2004 - Endocrine Soc The highly prevalent metabolic syndrome (insulin resistance, type 2 diabetes,
dyslipidemia, hypertension, along with abdominal obesity) resembles Cushing's
syndrome. However, in simple obesity, plasma cortisol levels are not ... Cited by 98 - Related articles - BL Direct - All 2 versions
- ►endojournals.org J Westerbacka, H Yki-Jarvinen, S … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc In Cushing's syndrome, cortisol causes fat accumulation in specific sites most
likely to be associated with insulin resistance, notably in omental adipose and
also perhaps in the liver. In idiopathic obesity, cortisol-metabolizing ... Cited by 93 - Related articles - BL Direct - All 6 versions
S Hummasti, BA Laffitte, MA Watson, C … - The Journal of Lipid Research, 2004 - ASBMB Page 1. Liver X receptors are regulators of adipocyte gene expression but not
differentiation. Identification of apoD as a direct target. ... Cited by 66 - Related articles - BL Direct - All 7 versions
- ►endojournals.org F Grun, B Blumberg - Endocrinology, 2006 - Endocrine Soc Over the last two decades, the incidence of obesity and associated metabolic
syndrome diseases has risen dramatically, becoming a global health crisis.
Increased caloric intake and decreased physical activity are believed to ... Cited by 56 - Related articles - BL Direct - All 10 versions
TM Stulnig, W Waldhäusl - Diabetologia, 2004 - Springer Obesity and Type 2 diabetes mellitus are associated with abnormal regulation of
glucocorticoid metabo- lism that are highlighted by clinical similarities be-
tween the sequelae of insulin resistance and Cushing's syndrome, as well as ... Cited by 45 - Related articles - BL Direct - All 5 versions
- ►endojournals.org NM Morton, L Ramage, JR Seckl - Endocrinology, 2004 - Endocrine Soc The enzyme 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD-1) amplifies
intracellular glucocorticoid action in vivo. 11ß-HSD-1 activity is increased in
adipose tissues of obese humans and genetically obese rodents, providing a ... Cited by 45 - Related articles - BL Direct - All 5 versions
