J Buteau, W El-Assaad, CJ Rhodes, L … - Diabetologia, 2004 - Springer Aims/hypothesis. We have provided evidence that gluca- gon-like peptide-1, a
potential therapeutic agent in the treatment of diabetes, activates
phosphatidylinositol-3 kinase/protein kinase B signalling in the pancreatic ... Cited by 112 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org R Roduit, C Nolan, C Alarcon, P Moore, A … - Diabetes, 2004 - Am Diabetes Assoc The malonyl-CoA/long-chain acyl-CoA (LC-CoA) model of glucose-induced insulin
secretion (GIIS) predicts that malonyl-CoA derived from glucose metabolism
inhibits fatty acid oxidation, thereby increasing the availability of ... Cited by 88 - Related articles - BL Direct - All 7 versions
S Khoo, SC Griffen, Y Xia, RJ Baer, MS … - Journal of Biological Chemistry, 2003 - ASBMB We show that the mitogen-activated protein kinases ERK1/2 are components of the
mechanism by which glucose stimulates insulin gene expression. ERK1/2 activity
is required for glucose-dependent transcription from both the full-length ... Cited by 65 - Related articles - BL Direct - All 4 versions
- ►cell.com KL Lipson, SG Fonseca, S Ishigaki, LX Nguyen, … - Cell Metabolism, 2006 - Elsevier In pancreatic β cells, the endoplasmic reticulum (ER) is an important site for
insulin biosynthesis and the folding of newly synthesized proinsulin. Here, we
show that IRE1α, an ER-resident protein kinase, has a crucial function in ... Cited by 63 - Related articles - All 13 versions
AM Efanov, S Sewing, K Bokvist, J Gromada - Diabetes, 2004 - Am Diabetes Assoc Liver X receptors (LXRs) α and β, transcription factors of a nuclear hormone
receptor family, are expressed in pancreatic islets as well as
glucagon-secreting and insulin-secreting cell lines. Culture of pancreatic ... Cited by 60 - Related articles - BL Direct - All 5 versions
- ►unige.ch [PDF] P Maechler, S Carobbio, B Rubi - International Journal of Biochemistry and Cell Biology, 2006 - Elsevier Pancreatic beta-cells are unique neuroendocrine cells displaying the peculiar
feature of responding to nutrients, principally glucose, as primary stimulus.
This requires translation of a metabolic substrate into intracellular ... Cited by 29 - Related articles - All 7 versions
LA Fahien, MJ MacDonald - Diabetes, 2002 - Am Diabetes Assoc Nutrient secretagogues can increase the production of succinyl-CoA in rat
pancreatic islets. When succinate esters are the secretagogue, succinyl-CoA can
be generated via the succinate thiokinase reaction. Other secretagogues can ... Cited by 25 - Related articles - BL Direct - All 5 versions
- ►cell.com Y Moriyama, M Hayashi - Trends in pharmacological sciences, 2003 - Elsevier Increasing evidence suggests that the excitatory neurotransmitter -glutamate
functions as a modulator in the islet of Langerhans, an endocrine organ involved
in blood glucose homeostasis. The islet is equipped with all the elements ... Cited by 21 - Related articles - All 8 versions
C Alarcon, B Wicksteed, CJ Rhodes - Diabetologia, 2006 - Springer Abstract Aims/hypothesis Ideally, a therapeutic insulin secretagogue should
coordinately increase insulin production and insulin secretion to maintain islet
beta cell secretory capacity. We compared the incretin mimetic exendin 4 ... Cited by 21 - Related articles - BL Direct - All 4 versions
DO Lambeth, KN Tews, S Adkins, D Frohlich, … - Journal of Biological Chemistry, 2004 - ASBMB For nearly 50 years, succinyl-CoA synthetase in animals was thought to be
specific for guanine nucleotides. Recently, we purified and characterized both
an ADP-forming succinyl-CoA synthetase from pigeon breast muscle and the ... Cited by 21 - Related articles - BL Direct - All 4 versions
