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Scholar Results 1 - 10 of about 91 citing Yoshida: PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells. (0.08 sec) 

Little evidence of transdifferentiation of bone marrow-derived cells into pancreatic beta cells


JB Choi, H Uchino, K Azuma, N Iwashita, Y … - Diabetologia, 2003 - Springer
Aims/hypothesis. Bone marrow cells contain at least two distinct types of stem
cells which are haemato- poietic stem cells and mesenchymal stem cells. Both
cells have the ability to differentiate into a variety of cell types ...
Cited by 134 - Related articles - BL Direct - All 3 versions

Transcription factors direct the development and function of pancreatic β cells

- cell.com
SK Chakrabarti, RG Mirmira - Trends in Endocrinology & Metabolism, 2003 - Elsevier
Transcription factors orchestrate intricate pathways of cellular growth and
differentiation by regulating the rate of transcription of an array of genes.
Genetic and biochemical studies have begun to unravel the complex cascade ...
Cited by 66 - Related articles - All 12 versions

Covalent Histone Modifications Underlie the Developmental Regulation of Insulin Gene …

- jbc.org
SK Chakrabarti, J Francis, SM Ziesmann, JC … - Journal of Biological Chemistry, 2003 - ASBMB
Histone modifying enzymes contribute to the activation or inactivation of
transcription by ultimately catalyzing the unfolding or further compaction,
respectively, of chromatin structure. Actively transcribed genes are ...
Cited by 60 - Related articles - BL Direct - All 5 versions

Role of oxidative stress in pancreatic beta-cell dysfunction


Y Kajimoto, H Kaneto - ANNALS-NEW YORK ACADEMY OF SCIENCES, 2004 - interscience.wiley.com
Abstract: Oxidative stress is produced under diabetic conditions and is likely
involved in progression of pancreatic β-cell dysfunction found in diabetes.
Possibly caused by low levels of antioxidant enzyme expressions, pancreatic ...
Cited by 58 - Related articles - BL Direct - All 5 versions

Expansion and redifferentiation of adult human pancreatic islet cells


L Ouziel-Yahalom, M Zalzman, L Anker-Kitai, S … - Biochemical and Biophysical Research …, 2006 - Elsevier
Type 1 diabetes is caused by autoimmune destruction of the pancreatic islet
insulin-producing β cells. Insulin administration does not prevent long-term
complications of the disease, since the optimal insulin dosage is difficult ...
Cited by 52 - Related articles - All 4 versions

PDX-1/VP16 fusion protein, together with NeuroD or Ngn3, markedly induces insulin gene …

- diabetesjournals.org
H Kaneto, Y Nakatani, T Miyatsuka, T … - Diabetes, 2005 - Am Diabetes Assoc
Diabetes is the most prevalent and serious metabolic disease, and the number of
diabetic patients worldwide is increasing. The reduction of insulin biosynthesis
in pancreatic β-cells is closely associated with the onset and progression ...
Cited by 50 - Related articles - All 6 versions

Oxidative stress, ER stress, and the JNK pathway in type 2 diabetes


H Kaneto, T Matsuoka, Y Nakatani, D … - Journal of Molecular Medicine, 2005 - Springer
Page 1. J Mol Med (2005) 83: 429–439 DOI 10.1007/s00109-005-0640-x REVIEW Hideaki
Kaneto . Taka-aki Matsuoka . Yoshihisa Nakatani . Dan Kawamori . ...
Cited by 46 - Related articles - All 3 versions

Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas …


T Miyatsuka, H Kaneto, Y Kajimoto, S Hirota, … - Biochemical and Biophysical Research …, 2003 - Elsevier
To date, the potency of pancreatic and duodenal homeobox gene 1 (PDX-1) in
inducing differentiation into insulin-producing cells has been demonstrated in
some cells and tissues. In order to carry out efficient screening of ...
Cited by 46 - Related articles - All 6 versions

Generation of insulin-producing cells from human bone marrow mesenchymal stem cells by …

- alphamedpress.org
O Karnieli, Y Izhar-Prato, S Bulvik, S Efrat - Stem Cells, 2007 - AlphaMed Press
We have recently shown that stable expression of pancreatic duodenal homeobox 1
(PDX1), a transcription factor that plays key roles in pancreas development and
β-cell gene expression, in cultured human fetal liver cells activates a ...
Cited by 39 - Related articles - BL Direct - All 6 versions

A chlorogenic acid-induced increase in GLP-1 production may mediate the impact of heavy …


MF McCarty - Medical hypotheses, 2005 - Elsevier
Recent prospective epidemiology links heavy coffee consumption to a substantial
reduction in risk for type 2 diabetes. Yet there is no evidence that coffee
improves insulin sensitivity and, at least in acute studies, caffeine has a ...
Cited by 37 - Related articles - All 26 versions


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