GA Rutter, GDS Xavier, I Leclerc - Biochemical Journal, 2003 - pubmedcentral.nih.gov AMPK (5 -AMP-activated protein kinase) is emerging as a meta- bolic master switch, by which
cells in both mammals and lower organisms sense and decode changes in energy status. Changes
in AMPK activity have been shown to regulate glucose transport in muscle and glucose ... Cited by 141 - Related articles - BL Direct - All 8 versions
- ►biologists.org H Wang, G Kouri, CB Wollheim - Journal of cell science, 2005 - jcs.biologists.org The reduction in insulin secretory capacity and ß-cell mass observed in type 2 diabetes is thought
to be caused by glucolipotoxicity secondary to hyperglycemia and hyperlipidemia. Our aim in
this study was to elucidate the underlying molecular mechanisms. We found a strong ... Cited by 104 - Related articles - BL Direct - All 7 versions
H Wang, P Maechler, PA Antinozzi, L Herrero, KA … - Journal of Biological …, 2003 - ASBMB Accumulation of lipids in non-adipose tissues is often associated with Type 2 diabetes and its
complications. Elevated expression of the lipogenic transcription factor, sterol regulatory element
binding protein-1c (SREBP-1c), has been demonstrated in islets and liver of diabetic ... Cited by 72 - Related articles - BL Direct - All 5 versions
IB Leibiger, B Leibiger, PO Berggren - FEBS letters, 2002 - Elsevier Pancreatic β-cell function is essential for the regulation of glucose homeostasis and its impairment
leads to diabetes mellitus. Besides glucose, the major nutrient factor, inputs from neural and
humoral components and intraislet cell–cell communication act together to guarantee an ... Cited by 65 - Related articles - All 6 versions
LM Cagen, X Deng, HG Wilcox, EA Park, R … - Biochemical …, 2005 - bj.portlandpress.com Page 1. 1 Insulin Activates the Rat Sterol Regulatory Element-Binding Protein 1c
(SREBP-1c) Promoter Through the Combinatorial Actions of SREBP, LXR, Sp-1, and
NF-Y cis -acting Elements Lauren M. CAGEN † , Xiong DENG ... Cited by 58 - Related articles - View as HTML - All 10 versions
- ►nih.gov [PDF] F Diraison, L Parton, P Ferré, F Foufelle, CP … - Biochemical …, 2004 - pubmedcentral.nih.gov Accumulation of intracellular lipid by pancreatic islet β-cells has been proposed to inhibit normal
glucose-regulated insulin secretion ('glucolipotoxicity'). In the present study, we determine whether
over-expression in rat islets of the lipogenic transcription factor SREBP1c ... Cited by 55 - Related articles - BL Direct - All 8 versions
- ►nih.gov [PDF] GDS Xavier, Q Qian, PJ Cullen, GA Rutter - Biochemical Journal, 2004 - pubmedcentral.nih.gov The importance of the insulin receptor (IR) and the insulin-like growth factor-1 receptor
(IGF-1R) for glucose-regulated insulin secretion and gene expression in pancreatic islet β-cells
is at present unresolved. Here, we have used small interfering RNAs (siRNAs) to silence ... Cited by 51 - Related articles - BL Direct - All 9 versions
- ►endojournals.org T Yamashita, K Eto, Y Okazaki, S Yamashita, T … - Endocrinology, 2004 - Endocrine Soc Triglyceride (TG) accumulation in pancreatic ß-cells is thought to be associated with impaired
insulin secretory response to glucose (lipotoxicity). To better understand the mechanism of the
impaired insulin secretory response to glucose in ß-cell lipotoxicity, we overexpressed a ... Cited by 51 - Related articles - BL Direct - All 3 versions
A Takahashi, K Motomura, T Kato, T Yoshikawa, Y … - Diabetes, 2005 - Am Diabetes Assoc Influx of excess fatty acids and the resultant accumulation of intracellular triglycerides are linked
to impaired insulin secretion and action in the pathogenesis of type 2 diabetes. Sterol regulatory
element-binding protein (SREBP)-1c is a transcription factor that controls cellular ... Cited by 43 - Related articles - All 5 versions
P Ferre, F Foufelle - Horm Res, 2007 - content.karger.com Insulin has long-term effects on glucose and lipid metabolism through its control on the expression
of specific genes. In insulin sensitive tissues and particularly in the liver, the transcription factor
sterol regulatory element binding protein-1c (SREBP-1c) transduces the insulin signal. ... Cited by 39 - Related articles - BL Direct - All 5 versions
