- ►nih.gov T Kitamura, J Nakae, Y Kitamura, Y Kido, … - Journal of Clinical …, 2002 - Am Soc Clin Investig Diabetes is caused by an absolute (type 1) or relative (type 2) deficiency of insulin-producing
β cells. The mechanisms governing replication of terminally differentiated β cells and neogenesis
from progenitor cells are unclear. Mice lacking insulin receptor substrate-2 (Irs2) develop ... Cited by 214 - Related articles - BL Direct - All 11 versions
J Jensen - Developmental Dynamics, 2004 - interscience.wiley.com The intensity of research on pancreatic development has increased markedly in the past 5
years, primarily for two reasons: we now know that the insulin-producing -cells normally arise
from an endodermally derived, pancreas-specified precursor cell, and successful ... Cited by 179 - Related articles - BL Direct - All 5 versions
- ►cell.com JE Gunton, RN Kulkarni, SH Yim, T Okada, WJ … - Cell, 2005 - Elsevier Type 2 diabetes is an epidemic disease affecting almost 200 million people worldwide (Zimmet
et al., 2001). The pathogenesis involves two core defects: insulin resistance and impaired β cell
function ([Martin et al., 1992], [Weyer et al., 1999] and [DeFronzo et al., 1992]). β cell ... Cited by 115 - Related articles - All 14 versions
- ►alphamedpress.org C Moriscot, F de Fraipont, MJ Richard, M Marchand, P … - Stem Cells, 2005 - AlphaMed Press Multipotential stem cells can be selected from the bone marrow by plastic adhesion,
expanded, and cultured. They are able to differentiate not only into multiple cell types, including
cartilage, bone, adipose and fibrous tissues, and myelosupportive stroma, but also into ... Cited by 114 - Related articles - All 7 versions
JM Servitja, J Ferrer - Diabetologia, 2004 - Springer Transcription factors provide the genetic instructions that drive pancreatic development and enable
mature beta cells to function properly. To understand fully how this is accomplished, it is necessary
to unravel the regulatory networks formed by transcription fac- tors acting on their ... Cited by 107 - Related articles - BL Direct - All 4 versions
- ►nih.gov RK Gupta, MZ Vatamaniuk, CS Lee, RC … - Journal of Clinical …, 2005 - Am Soc Clin Investig Mutations in the gene encoding hepatocyte nuclear factor-4α (HNF-4α) result in maturity-onset
diabetes of the young (MODY). To determine the contribution of HNF-4α to the maintenance
of glucose homeostasis by the β cell in vivo, we derived a conditional knockout of HNF-4α ... Cited by 75 - Related articles - All 7 versions
- ►diabetesjournals.org Y Li, X Cao, LX Li, PL Brubaker, H Edlund, DJ Drucker - Diabetes, 2005 - Am Diabetes Assoc Glucagon-like peptide-1 (GLP-1) regulates energy intake, gastrointestinal motility, and nutrient
disposal. The relative importance of the islet β-cell for GLP-1 actions remains unclear. We determined
the role of the islet β-cell and the pancreatic duodenal homeobox-1 (Pdx1) transcription ... Cited by 71 - Related articles - All 6 versions
- ►nih.gov KA Lantz, MZ Vatamaniuk, JE Brestelli, JR … - Journal of Clinical …, 2004 - Am Soc Clin Investig The regulation of insulin secretion by pancreatic β cells is perturbed in several diseases, including
adult-onset (type 2) diabetes and persistent hyperinsulinemic hypoglycemia of infancy
(PHHI). The first mouse model for PHHI has a conditional deletion of the gene encoding ... Cited by 68 - Related articles - BL Direct - All 8 versions
- ►ahajournals.org M Abid… - Arteriosclerosis, thrombosis, and vascular biology, 2004 - Am Heart Assoc Methods and Results— We demonstrate that human ECs express members of the forkhead family
(FKHR, FKHRL1, and AFX) and that VEGF modulates the phosphorylation, subcellular
localization, and transcriptional activity of one or more of these isoforms by a PI3K/Akt ... Cited by 71 - Related articles - BL Direct - All 9 versions
C Wolfrum, D Besser, E Luca, M … - Proceedings of the …, 2003 - National Acad Sciences Hepatocyte nuclear factors 3 α, β, and γ (Foxa-1, -2, and -3) are transcriptional activators of important
metabolic genes in the liver that are suppressed by the actions of insulin. Here, we show that
the activation of phosphatidylinositol 3-kinase–Akt by insulin induces Foxa-2 ... Cited by 67 - Related articles - BL Direct - All 10 versions
