- ►aspetjournals.org NG Abraham, A Kappas - Pharmacological reviews, 2008 - ASPET This review is intended to stimulate interest in the effect of increased
expression of heme oxygenase-1 (HO-1) protein and increased levels of HO
activity on normal and pathological states. The HO system includes the heme ... Cited by 88 - Related articles - All 6 versions
- ►diabetesjournals.org R Bottino, AN Balamurugan, H Tse, C … - Diabetes, 2004 - Am Diabetes Assoc The process of human islet isolation triggers a cascade of stressful events in
the islets of Langerhans involving activation of apoptosis and necrosis and the
production of proinflammatory molecules that negatively influence islet ... Cited by 72 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org I Cozar-Castellano, KK Takane, R Bottino, … - Diabetes, 2004 - Am Diabetes Assoc The major regulator of the gap-1/synthesis phase (G 1 /S) cell cycle checkpoint
is the retinoblastoma protein (pRb), and this is regulated in part by the
activities of cyclin-dependent kinase (cdk)-4 and the D cyclins. ... Cited by 57 - Related articles - BL Direct - All 4 versions
- ►endojournals.org I Cozar-Castellano, N Fiaschi-Taesch, TA … - Endocrine reviews, 2006 - Endocrine Soc Type 1 and type 2 diabetes both result from inadequate production of insulin by
the ß-cells of the pancreatic islet. Accordingly, strategies that lead to
increased pancreatic ß-cell mass, as well as retained or enhanced function ... Cited by 54 - Related articles - BL Direct - All 5 versions
KK Rehman, S Bertera, R Bottino, AN … - Journal of Biological Chemistry, 2003 - ASBMB We have previously demonstrated that adenoviral gene transfer of the NF-κB
inhibitor IκB to human islets results in protection from interleukin
(IL)-1β-mediated dysfunction and apoptosis. Here we report that human and ... Cited by 53 - Related articles - BL Direct - All 4 versions
R Bottino, P Lemarchand, M Trucco, N … - Gene Therapy, 2003 - nature.com Type 1 diabetes mellitus, an autoimmune disorder is an attractive candidate for
gene and cell-based therapy. From the use of gene-engineered immune cells to
induce hyporesponsiveness to autoantigens to islet and beta cell surrogate ... Cited by 44 - Related articles - BL Direct - All 4 versions
- ►alfediam.org [PDF] NF Wiernsperger - Diabetes and Metabolism, 2003 - Elsevier Oxidative stress has been repetitively shown to be a hallmark of many diseases
linked with metabolic or vascular disorders. Therefore diabetes represents an
ideal candidate for studying the consequences of oxidative stress and its ... Cited by 44 - Related articles - BL Direct - All 7 versions
- ►endojournals.org RD Hoeldtke, KD Bryner, DR McNeill, SS … - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc The purpose of this study was to analyze biochemical measures of oxidative
stress and assess their relationship to insulin requirements early in type 1
diabetes. Thirty-seven patients enrolled in a 3-yr longitudinal study of ... Cited by 41 - Related articles - BL Direct - All 5 versions
BJ Day - Drug discovery today, 2004 - Elsevier In humans, several pathologies involve the overproduction of reactive oxygen
species. Metal-containing catalytic antioxidants have emerged as a novel class
of potential therapeutic agents that scavenge a wide range of reactive ... Cited by 39 - Related articles - All 6 versions
- ►diabetesjournals.org VV Tran, G Chen, CB Newgard, HE Hohmeier - Diabetes, 2003 - Am Diabetes Assoc We have been investigating the potential utility of engineered cell lines as
surrogates for primary islet cells in treatment of type 1 diabetes. To this end,
two strategies that have emerged for procuring cell lines with resistance ... Cited by 36 - Related articles - BL Direct - All 4 versions
