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Scholar Results 1 - 10 of about 108 citing Young: Impaired long-chain fatty acid oxidation and contractile dysfunction in the obese.... (0.08 sec) 

Obesity and suppressed B-type natriuretic peptide levels in heart failure

- onlinejacc.org
MR Mehra, PA Uber, MH Park, RL Scott, HO … - Journal of the American …, 2004 - Elsevier
A total of 318 patients with heart failure were evaluated between June 2001 and June 2002.
Levels of BNP were compared in obese (body mass index [BMI] ≥30 kg/m 2 ) and nonobese
(BMI <30 kg/m 2 ) patients with respect to New York Heart Association functional class ...
Cited by 182 - Related articles - BL Direct - All 7 versions

Nuclear receptor signaling and cardiac energetics

- ahajournals.org
JM Huss, DP Kelly - Circulation Research, 2004 - Am Heart Assoc
The heart has a tremendous capacity for ATP generation, allowing it to function as an efficient
pump throughout the life of the organism. The adult myocardium uses either fatty acid or glucose
oxidation as its main energy source. Under normal conditions, the adult heart derives ...
Cited by 155 - Related articles - BL Direct - All 8 versions

Intramyocardial lipid accumulation in the failing human heart resembles the …

- fasebj.org
S Sharma, JV Adrogue, L Golfman, I Uray, J Lemm, K … - The FASEB Journal, 2004 - FASEB
In animal models of lipotoxicity, accumulation of triglycerides within cardiomyocytes is associated
with contractile dysfunction. However, whether intramyocardial lipid deposition is a feature of
human heart failure remains to be established. We hypothesized that intramyocardial lipid ...
Cited by 140 - Related articles - BL Direct - All 3 versions

Transgenic expression of fatty acid transport protein 1 in the heart causes lipotoxic …

- ahajournals.org [PDF] 
HC Chiu, A Kovacs, RM Blanton, X Han, M … - Circulation …, 2005 - Am Heart Assoc
Kluwer Health, 351 West Camden Street, Baltimore, MD 21202-2436. Phone:
410-528-4050. Permissions: Permissions & Rights Desk, Lippincott Williams & Wilkins, a division
of Wolters ... Transgenic Expression of Fatty Acid Transport Protein 1
Cited by 144 - Related articles - All 8 versions

Diabetic cardiomyopathy revisited


S Boudina, ED Abel - Circulation, 2007 - Am Heart Assoc
The prevalence of diabetes mellitus is growing rapidly. It is estimated that globally the number
of adults affected with diabetes will increase from 135 million in 1995 to 300 million by 2025.
1 Patients with diabetes mellitus are at increased risk for cardiovascular diseases. Thus, ...
Cited by 140 - Related articles - All 5 versions

Myocardial triglycerides and systolic function in humans: in vivo evaluation by …


LS Szczepaniak, RL Dobbins, GJ Metzger, … - Magnetic …, 2003 - interscience.wiley.com
Recent experimental data suggest that adiposity directly damages the heart by promoting ectopic
deposition of triglyceride, a process known as myocardial steatosis. The goal of this study was
to develop and validate proton magnetic resonance spectroscopy ( 1 H MRS) as an in ...
Cited by 124 - Related articles - BL Direct - All 3 versions

Diabetic cardiomyopathy: the search for a unifying hypothesis


IG Poornima, P Parikh, RP Shannon - Circulation research, 2006 - Am Heart Assoc
Although diabetes is recognized as a potent and prevalent risk factor for ischemic heart
disease, less is known as to whether diabetes causes an altered cardiac phenotype independent
of coronary atherosclerosis. Left ventricular systolic and diastolic dysfunction, left ...
Cited by 116 - Related articles - All 7 versions

Cardiac lipid accumulation associated with diastolic dysfunction in obese mice


C Christoffersen, E Bollano, MLS Lindegaard, ED … - Endocrinology, 2003 - Endocrine Soc
Obesity may confer cardiac dysfunction due to lipid accumulation in cardiomyocytes. To test this
idea, we examined whether obese ob/ob mice display heart lipid accumulation and cardiac
dysfunction. Ob/ob mouse hearts had increased expression of genes mediating ...
Cited by 110 - Related articles - BL Direct - All 4 versions

Long-chain fatty acid uptake and FAT/CD36 translocation in heart and skeletal …

- sc.edu [PDF] 
DPY Koonen, JFC Glatz, A Bonen, JJFP Luiken - BBA-Molecular and Cell …, 2005 - Elsevier
Cellular long-chain fatty acid (LCFA) uptake constitutes a process that is not yet fully
understood. LCFA uptake likely involves both passive diffusion and protein-mediated
transport. Several lines of evidence support the involvement of a number of plasma ...
Cited by 83 - Related articles - All 4 versions

Fatty acid metabolism is enhanced in type 2 diabetic hearts


AN Carley, DL Severson - BBA-Molecular and Cell Biology of Lipids, 2005 - Elsevier
The metabolic phenotype of hearts has been investigated using rodent models of type 2 diabetes
which exhibit obesity and insulin resistance: db/db and ob/ob mice, and Zucker fatty and ZDF
rats. In general, cardiac fatty acid (FA) utilization is enhanced in type 2 diabetic hearts, ...
Cited by 73 - Related articles - All 3 versions


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