IG Obrosova, F Li, OI Abatan, MA Forsell, K Komjáti, P … - Diabetes, 2004 - Am Diabetes Assoc Oxidative and nitrosative stress play a key role in the pathogenesis of diabetic neuropathy, but
the mechanisms remain unidentified. Here we provide evidence that poly(ADP-ribose) polymerase
(PARP) activation, a downstream effector of oxidant-induced DNA damage, is an ... Cited by 88 - Related articles - BL Direct - All 10 versions
IG Obrosova, P Pacher, C Szabó, Z Zsengeller, H … - Diabetes, 2005 - Am Diabetes Assoc This study evaluated the effects of aldose reductase inhibition on diabetes-induced
oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation. In animal
experiments, control and streptozotocin-induced diabetic rats were treated with or without ... Cited by 73 - Related articles - All 8 versions
DM Niedowicz, DL Daleke - Cell biochemistry and biophysics, 2005 - Springer The morbidity and mortality associated with diabetes is the result of the myriad complications
related to the disease. One of the most explored hypotheses to explain the onset of complications
is a hyperglycemia-induced increase in oxidative stress. Reactive oxygen species (ROS) ... Cited by 53 - Related articles - BL Direct - All 6 versions
R Pop-Busui, A Sima, M Stevens - Diabetes/Metabolism Reviews - interscience.wiley.com This review will focus on the impact of hyperglycemia-induced oxidative stress in the development
of diabetes-related neural dysfunction. Oxidative stress occurs when the balance between the
production of reactive oxygen species (ROS) and the ability of cells or tissues to detoxify ... Cited by 42 - Related articles - BL Direct - All 3 versions
- ►inotekcorp.com [PDF] F Li, C Szabo, P Pacher, GJ Southan, OI Abatan, T … - Diabetologia, 2004 - Springer Aims/hypothesis. Poly(ADP-ribose) polymerase acti- vation depletes NAD + and high-energy
phosphates, activates protein kinase C, and affects gene expression in various tissues. This
study was designed to charac- terise the effects of the potent, orally active ... Cited by 38 - Related articles - BL Direct - All 11 versions
IG Obrosova, VR Drel, P Pacher, O Ilnytska, ZQ Wang, … - Diabetes, 2005 - Am Diabetes Assoc Poly(ADP-ribose) polymerase (PARP) activation, an important factor in the pathogenesis of diabetes
complications, is considered a downstream effector of oxidative-nitrosative stress. However,
some recent findings suggest that it is not necessarily the case and that PARP activation ... Cited by 38 - Related articles - BL Direct - All 11 versions
- ►physiology.org MJ Stevens, W Zhang, F Li, AAF … - American Journal of …, 2004 - Am Physiological Soc Oxidative stress and neurovascular dysfunction have emerged as contributing factors to the development
of experimental diabetic neuropathy (EDN) in streptozotocin-diabetic rodents. Additionally, depletion
of C-peptide has been implicated in the pathogenesis of EDN, but the mechanisms of ... Cited by 33 - Related articles - All 4 versions
C Krarup - Current opinion in neurology, 2003 - journals.lww.com Recent findings: Electrodiagnostic studies have relevance in distinguishing neuropathies with
different etiologies in diabetes mellitus, and different strategies and methods are necessary to
study patients with autonomic and small-fiber involvement. The involvement of motor or ... Cited by 27 - Related articles - BL Direct - All 5 versions
- ►prsjournal.com M Siemionow, Y Demir - Journal of reconstructive microsurgery, 2004 - thieme-connect.com Neuropathy is a common and devastating complication of diabetes that contributes to mortality
in most cases. Multiple factors are thought to play a major role in the pathogenesis of diabetic
neuropathy, including alterations in the endoneural metabolism, defective neurotrophic ... Cited by 29 - Related articles - BL Direct - All 6 versions
SI Yamagishi, K Uehara, S Otsuki, S … - Journal of …, 2003 - interscience.wiley.com To explore the relationship between polyol pathway and protein kinase C (PKC), we examined
PKC activities and expressions of PKC isoforms separately in endoneurial and vessel-rich epineurial
tissues in diabetic mice transgenic for human aldose reductase (Tg). Tg and littermate ... Cited by 25 - Related articles - BL Direct - All 4 versions
