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Scholar Results 1 - 10 of about 25 citing Fahien: The succinate mechanism of insulin release. (0.10 sec) 

Perspective: emerging evidence for signaling roles of mitochondrial anaplerotic products in …

- physiology.org
MJ MacDonald, LA Fahien, LJ Brown, NM … - American Journal of Physiology- Endocrinology And …, 2005 - Am Physiological Soc
The importance of mitochondrial biosynthesis in stimulus secretion coupling in
the insulin-producing -cell probably equals that of ATP production. In
glucose-induced insulin secretion, the rate of pyruvate carboxylation is ...
Cited by 60 - Related articles - All 4 versions

Glucose Suppresses Superoxide Generation in Metabolically Responsive Pancreatic {beta} …

- jbc.org
GA Martens, Y Cai, S Hinke, G Stange, M Van … - Journal of Biological Chemistry, 2005 - ASBMB
High rates of glucose metabolism and mitochondrial electron transport have been
associated with increased mitochondrial production of reactive oxygen species
(ROS). This mechanism was also proposed as a possible cause for dysfunction ...
Cited by 32 - Related articles - All 6 versions

MTHFR gene polymorphism as a risk factor for diabetic retinopathy in type 2 diabetic …

- diabetesjournals.org [PDF] 
M Maeda, I Yamamoto, M Fukuda, M Nishida, J … - Diabetes Care, 2003 - Am Diabetes Assoc
Cross-sectional studies of the com- bined intima-media wall thickness (IMT) of
the carotid arteries per- formed in type 1 diabetic patients show partly
contradictory results with regard to variables that are associated with the ...
Cited by 27 - Related articles - BL Direct - All 5 versions

A role for ATP-citrate lyase, malic enzyme, and pyruvate/citrate cycling in glucose-induced …

- shouxi.net
C Guay, SR Madiraju, A Aumais, E Joly, M … - Journal of Biological Chemistry, 2007 - ASBMB
In pancreatic β-cells, metabolic coupling factors generated during glucose
metabolism and pyruvate cycling through anaplerosis/cataplerosis processes
contribute to the regulation of insulin secretion. Pyruvate/citrate cycling ...
Cited by 25 - Related articles - All 4 versions

A low glycemic diet significantly improves the 24-h blood glucose profile in people with …

- diabetesjournals.org [PDF] 
AE Brynes, JL Lee, RE Brighton, AR Leeds, A … - Diabetes Care, 2003 - Am Diabetes Assoc
Cross-sectional studies of the com- bined intima-media wall thickness (IMT) of
the carotid arteries per- formed in type 1 diabetic patients show partly
contradictory results with regard to variables that are associated with the ...
Cited by 17 - Related articles - BL Direct - All 6 versions

Enhanced mitochondrial metabolism may account for the adaptation to insulin resistance in …


M Fex, MD Nitert, N Wierup, F Sundler, C Ling … - Diabetologia, 2007 - Springer
Abstract Aim/hypothesis Hyperinsulinaemia maintains euglycaemia in
insulin-resistant states. The precise cellular mechanisms by which the beta
cells adapt are still unresolved. A peripherally derived cue, such as ...
Cited by 16 - Related articles - BL Direct - All 4 versions

Feasibility of pathways for transfer of acyl groups from mitochondria to the cytosol to form …

- jbc.org
MJ MacDonald, AD Smith III, NM Hasan, G … - Journal of Biological Chemistry, 2007 - ASBMB
The mitochondria of pancreatic beta cells are believed to convert insulin
secretagogues into products that are translocated to the cytosol where they
participate in insulin secretion. We studied the hypothesis that short ...
Cited by 15 - Related articles - All 5 versions

P2Y purinergic potentiation of glucose-induced insulin secretion and pancreatic beta-cell …


A Farret, M Vignaud, S Dietz, J Vignon, P … - Diabetes, 2004 - Am Diabetes Assoc
Purine nucleotides and their analogs increase insulin secretion through
activation of pancreatic β-cell P2Y receptors. The present study aimed at
determining the role of glucose metabolism in the response to P2Y agonists ...
Cited by 12 - Related articles - BL Direct - All 5 versions

Synergistic potent insulin release by combinations of weak secretagogues in pancreatic …

- jbc.org
MJ MacDonald - Journal of Biological Chemistry, 2007 - ASBMB
Insulin secretion by the beta cell depends on anaplerosis in which insulin
secretagogues are metabolized by mitochondria into molecules that are most
likely exported to the extramitochondrial space where they have signaling ...
Cited by 13 - Related articles - All 7 versions

Insights into the role of anaplerosis in insulin secretion: A 13 C NMR study


NE Simpson, N Khokhlova, JA Oca-Cossio, I … - Diabetologia, 2006 - Springer
Page 1. Diabetologia (2006) 49: 1338–1348 DOI 10.1007/s00125-006-0216-5 ARTICLE
NE Simpson . N. Khokhlova . JA Oca-Cossio . I. Constantinidis ...
Cited by 11 - Related articles - BL Direct - All 3 versions


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