- ►nih.gov S Krauss, CY Zhang, L Scorrano, LT Dalgaard, … - Journal of Clinical Investigation, 2003 - Am Soc Clin Investig Failure to secrete adequate amounts of insulin in response to increasing
concentrations of glucose is an important feature of type 2 diabetes. The
mechanism for loss of glucose responsiveness is unknown. Uncoupling protein ... Cited by 193 - Related articles - BL Direct - All 11 versions
- ►pnas.org MP Czubryt, J McAnally, GI Fishman, EN … - Proceedings of the National Academy of Sciences, 2003 - National Acad Sciences The myocyte enhancer factor-2 (MEF2) transcription factor regulates muscle
development and calcium-dependent gene expression. MEF2 activity is repressed by
class II histone deacetylases (HDACs), which dissociate from MEF2 when ... Cited by 159 - Related articles - BL Direct - All 6 versions
- ►cell.com P Steneberg, N Rubins, R Bartoov-Shifman, … - Cell metabolism, 2005 - Elsevier Obesity is typically associated with elevated levels of free fatty acids (FFAs)
and is linked to glucose intolerance and type 2 diabetes. FFAs exert divergent
effects on insulin secretion from β cells: acute exposure to FFAs ... Cited by 113 - Related articles - All 11 versions
S Del Guerra, R Lupi, L Marselli, M Masini, M … - Diabetes, 2005 - Am Diabetes Assoc To shed further light on the primary alterations of insulin secretion in type 2
diabetes and the possible mechanisms involved, we studied several functional and
molecular properties of islets isolated from the pancreata of 13 type 2 ... Cited by 107 - Related articles - All 5 versions
- ►diabetesjournals.org CB Chan, MC Saleh, V Koshkin, MB Wheeler - Diabetes, 2004 - Am Diabetes Assoc Stressors such as chronic hyperglycemia or hyperlipidemia may lead to
insufficient insulin secretion in susceptible individuals, contributing to type
2 diabetes. The molecules mediating this effect are just beginning to be ... Cited by 84 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org MW Fariss, CB Chan, M Patel, B Van Houten, … - Molecular interventions, 2005 - ASPET Oxidative stress and mitochondrial oxidative damage have been implicated in the
etiology of numerous common diseases. The critical mitochondrial events
responsible for oxidative stress–mediated cell death (toxic oxidative ... Cited by 69 - Related articles - All 2 versions
- ►oxfordjournals.org F Ashcroft, P Rorsman - Human molecular genetics, 2004 - Oxford Univ Press Type 2 diabetes mellitus is a serious metabolic disease that afflicts around 5%
of the population in Western societies and over 150 million people worldwide. It
is characterized by elevation of the blood glucose concentration, usually ... Cited by 70 - Related articles - All 5 versions
- ►endojournals.org V Poitout, RP Robertson - Endocrine reviews, 2008 - Endocrine Soc Glucotoxicity, lipotoxicity, and glucolipotoxicity are secondary phenomena that
are proposed to play a role in all forms of type 2 diabetes. The underlying
concept is that once the primary pathogenesis of diabetes is established, ... Cited by 71 - Related articles - BL Direct - All 7 versions
S Winzell… - Diabetes, 2003 - Am Diabetes Assoc Lipid perturbations associated with triglyceride overstorage in β-cells impair
insulin secretion, a process termed lipotoxicity. To assess the role of
hormone-sensitive lipase, which is expressed and enzymatically active in β- ... Cited by 52 - Related articles - BL Direct - All 4 versions
X Wang, H Li, D De Leo, W Guo, V Koshkin, … - Diabetes, 2004 - Am Diabetes Assoc Gene and Protein Kinase Expression Profiling of ... Reactive Oxygen
Species–Associated Lipotoxicity in the ... Xiaolin Wang, 1 * Hui Li, 1,2 *
Domenica De Leo, 1 Wanbei Guo, 2 Vasilij Koshkin, 1 I. George Fantus, 1,3 Cited by 50 - Related articles - BL Direct - All 4 versions
