- ►yu.edu [PDF] TKT Lam, A Pocai, R Gutierrez-Juarez, S Obici … - Nature medicine, 2005 - medscape.com Increased glucose production is a hallmark of type 2 diabetes and alterations in
lipid metabolism have a causative role in its pathophysiology. Here we postulate
that physiological increments in plasma fatty acids can be sensed within ... Cited by 117 - Related articles - All 9 versions
- ►diabetesjournals.org P Proks, F Reimann, N Green, F Gribble, F … - Diabetes, 2002 - Am Diabetes Assoc Sulfonylureas are widely used to treat type 2 diabetes because they stimulate
insulin secretion from pancreatic ß-cells. They primarily act by binding to the
SUR subunit of the ATP-sensitive potassium (K ATP ) channel and inducing ... Cited by 115 - Related articles - BL Direct - All 3 versions
FM Gribble, F Reimann - Diabetologia, 2003 - Springer Hypoglycaemic agents such as sulphonylureas and the newer group of
“glinides” stimulate insulin secretion by closing ATP-sensitive potassium (K
ATP ) channels in pancreatic beta cells, but have varying cross-reac- ... Cited by 106 - Related articles - BL Direct - All 3 versions
- ►adisonline.com [PDF] M Rendell - Drugs, 2004 - ingentaconnect.com The sulphonylureas act by triggering insulin release from the pancreatic β
cell. Abstract A specific site on the adenosine triphosphate (ATP)-sensitive
potassium channels is occupied by sulphonylureas leading to closure of the ... Cited by 86 - Related articles - BL Direct - All 7 versions
- ►endojournals.org K Maedler, RD Carr, D Bosco, RA Zuellig, T … - Journal of Clinical Endocrinology & Metabolism, 2005 - Endocrine Soc Loss of ß-cell mass and function raises a concern regarding the application of
sulfonylureas for the treatment of type 2 diabetes because previous studies have
shown that agents that cause closure of inwardly rectifying K + ... Cited by 77 - Related articles - All 6 versions
J Rosenstock, DR Hassman, RD Madder, SA … - Diabetes Care, 2004 - Am Diabetes Assoc RESEARCH DESIGN AND METHODS—Enrolled patients (n = 150) had received treatment
with diet and exercise in the previous 3 months with HbA 1c >7 and ≤12%.
Patients were randomized to receive monotherapy with repaglinide (n = 76) ... Cited by 60 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org U Quast, D Stephan, S Bieger, U Russ - Diabetes, 2004 - Am Diabetes Assoc Insulin secretagogues (sulfonylureas and glinides) increase insulin secretion by
closing the ATP-sensitive K + channel (K ATP channel) in the pancreatic β-cell
membrane. K ATP channels subserve important functions also in the heart. ... Cited by 58 - Related articles - BL Direct - All 4 versions
J Bryan, A Crane, WH Vila-Carriles, AP … - Current pharmaceutical design, 2005 - ingentaconnect.com Abstract: ATP-sensitive K + channels, termed K ATP channels, provide a link
between cellular metabolism and membrane electrical activity in a variety of
tissues. Channel isoforms have been identified and are targets for ... Cited by 37 - Related articles - BL Direct - All 4 versions
P Proks, JD Lippiat - Current pharmaceutical design, 2006 - ingentaconnect.com Abstract: Type-2, or non-insulin-dependent diabetes mellitus is a serious
disease that is now widespread throughout Western society. Glucose intolerance,
or failure of glucose to stimulate insulin secretion, is a primary factor ... Cited by 19 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org M Chachin, M Yamada, A Fujita, T Matsuoka, K … - Journal of Pharmacology and Experimental …, 2003 - ASPET A novel antidiabetic agent, nateglinide, is a D-phenylalanine derivative lacking
either a sulfonylurea or benzamido moiety. We examined with the patch-clamp
method the effect of nateglinide on recombinant ATP-sensitive K + (K ATP ) ... Cited by 20 - Related articles - BL Direct - All 3 versions
