- ►ahajournals.org A Goldin, JA Beckman, AM Schmidt, MA … - Circulation, 2006 - Am Heart Assoc Advanced glycation end products (AGEs) are proteins or lipids that become
glycated after exposure to sugars. AGEs are prevalent in the diabetic
vasculature and contribute to the development of atherosclerosis. The ... Cited by 184 - Related articles - All 7 versions
- ►ahajournals.org JL Wautier, AM Schmidt - Circulation research, 2004 - Am Heart Assoc The advanced glycation end products (AGEs) are a heterogeneous class of
molecules, including the following main subgroups: bis(lysyl)imidazolium
cross-links, hydroimidazolones, 3-deoxyglucosone derivatives, and monolysyl ... Cited by 167 - Related articles - BL Direct - All 7 versions
- ►asnjournals.org T Wendt, N Tanji, J Guo, BI Hudson, A … - Journal of the American Society of Nephrology, 2003 - Am Soc Nephrol Irrespective of the underlying mechanisms, elevated levels of blood glucose
ignite a vicious cycle of metabolic disturbances within the intracellular and
extracellular environment that, if left unchecked, lead to a broad array of ... Cited by 137 - Related articles - BL Direct - All 6 versions
S Yamagishi, T Imaizumi - Current pharmaceutical design, 2005 - ingentaconnect.com Abstract: Diabetic vascular complication is a leading cause of end-stage renal
failure, acquired blindness, a variety of neuropathies and accelerated
atherosclerosis, which could account for disabilities and high mortality ... Cited by 123 - Related articles - All 3 versions
S Vasan, P Foiles, H Founds - Archives of Biochemistry and Biophysics, 2003 - Elsevier Long-lived structural proteins, collagen and elastin, undergo continual
non-enzymatic crosslinking during aging and in diabetic individuals. This
abnormal protein crosslinking is mediated by advanced glycation end ... Cited by 93 - Related articles - All 4 versions
LA Martinez-Lemus, X Wu, E Wilson, MA Hill, … - Journal of Vasc Res, 2003 - content.karger.com Cells within the vascular wall connect their cytoskeleton to the extracellular
matrix (ECM) through a family of cell surface receptors known as integrins. The
ability of integrins to act as a link between the extracellular and ... Cited by 78 - Related articles - BL Direct - All 7 versions
RA Kowluru, P Koppolu, S Chakrabarti, S … - Free radical research, 2003 - informahealthcare.com Oxidative stress is increased in the retina in diabetes, and long-term
administration of antioxidants inhibits the development of retinopathy in
diabetic rats. The purpose of this study is to determine how diabetes ... Cited by 75 - Related articles - BL Direct - All 8 versions
- ►diabetesjournals.org RA Kowluru, S Odenbach - Diabetes, 2004 - Am Diabetes Assoc Oxidative stress is increased in the retina in diabetes, and it is considered to
play an important role in the development of retinopathy. α-Lipoic acid, a
thiol antioxidant, has been shown to have beneficial effects on ... Cited by 73 - Related articles - BL Direct - All 6 versions
- ►iovs.org F Schutt, M Bergmann, FG Holz, J Kopitz - Investigative ophthalmology & visual science, 2003 - ARVO METHODS. LF was isolated from the RPE-choroid complex of 10 pairs of donor eyes
by gradient ultracentrifugation. Protein compounds were separated by
two-dimensional (2-D) gel electrophoresis and screened by Western blot ... Cited by 72 - Related articles - BL Direct - All 3 versions
