EMD Nielsen, L Hansen, B Carstensen, SM … - Diabetes, 2003 - Am Diabetes Assoc The E23K polymorphism of the pancreatic β-cell ATP-sensitive K + (K ATP )
channel subunit Kir6.2 (KCNJ11) is associated with type 2 diabetes in whites,
and a recent in vitro study of the E23K variant suggests that the ... Cited by 147 - Related articles - BL Direct - All 5 versions
- ►nih.gov FM Ashcroft - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig ATP-sensitive potassium (K ATP ) channels, so named because they are inhibited
by intracellular ATP , play key physiological roles in many tissues. In
pancreatic β cells, these channels regulate glucose-dependent insulin ... Cited by 142 - Related articles - BL Direct - All 14 versions
AT Hattersley, FM Ashcroft - Diabetes, 2005 - Am Diabetes Assoc Closure of ATP-sensitive K + channels (K ATP channels) in response to
metabolically generated ATP or binding of sulfonylurea drugs stimulates insulin
release from pancreatic β-cells. Heterozygous gain-of-function mutations ... Cited by 138 - Related articles - BL Direct - All 10 versions
- ►oxfordjournals.org F Ashcroft, P Rorsman - Human molecular genetics, 2004 - Oxford Univ Press Type 2 diabetes mellitus is a serious metabolic disease that afflicts around 5%
of the population in Western societies and over 150 million people worldwide. It
is characterized by elevation of the blood glucose concentration, usually ... Cited by 70 - Related articles - All 5 versions
- ►endojournals.org J Gromada, I Franklin, CB Wollheim - Endocrine reviews, 2007 - Endocrine Soc Glucagon, a hormone secreted from the -cells of the endocrine pancreas, is
critical for blood glucose homeostasis. It is the major counterpart to insulin
and is released during hypoglycemia to induce hepatic glucose output. The ... Cited by 61 - Related articles - BL Direct - All 4 versions
L Hansen, O Pedersen - Diabetes Obesity and Metabolism, 2005 - interscience.wiley.com Throughout the last decade, molecular genetic studies of non-autoimmune diabetes
mellitus have contributed significantly to our present understanding of this
disease's complex aetiopathogenesis. Monogenic forms of diabetes ... Cited by 54 - Related articles - All 4 versions
- ►nih.gov SA Schäfer, O Tschritter, F Machicao, C Thamer … - Diabetologia, 2007 - Springer Page 1. ARTICLE Impaired glucagon-like peptide-1-induced insulin secretion in carriers
of transcription factor 7-like 2 (TCF7L2) gene polymorphisms ... Cited by 57 - Related articles - BL Direct - All 9 versions
T Miki, S Seino - Journal of molecular and cellular cardiology, 2005 - Elsevier Physiological and pathophysiological roles of K ATP channels have been clarified
recently in genetically engineered mice. The Kir6.2-containing K ATP channels in
pancreatic ß-cells and the hypothalamus are essential in the regulation of ... Cited by 52 - Related articles - All 6 versions
- ►hivinfosource.org [PDF] MJ Riedel, P Boora, D Steckley, G de Vries, … - Diabetes, 2003 - Am Diabetes Assoc The commonly occurring E23K and I337V Kir6.2 polymorphisms in the ATP-sensitive
potassium (K ATP ) channel are more frequent in Caucasian type 2 diabetic
populations. However, the underlying cellular mechanisms contributing to ... Cited by 51 - Related articles - BL Direct - All 25 versions
- ►diabetesjournals.org JC Koster, MA Permutt, CG Nichols - Diabetes, 2005 - Am Diabetes Assoc The ATP-sensitive K + channel (K ATP channel) senses metabolic changes in the
pancreatic β-cell, thereby coupling metabolism to electrical activity and
ultimately to insulin secretion. When K ATP channels open, β-cells ... Cited by 43 - Related articles - BL Direct - All 5 versions
