SK Das, SJ Hasstedt, Z Zhang, SC Elbein - Diabetes, 2004 - Am Diabetes Assoc We have identified a region on chromosome 1q21-q24 that was significantly linked to type 2
diabetes in multiplex families of Northern European ancestry and also in Pima Indians, Amish
families, and families from France and England. We sought to narrow and map this locus ... Cited by 43 - Related articles - BL Direct - All 6 versions
SH Fatemi, TJ Reutiman, TD Folsom, C … - …, 2006 - muse.lib.nchu.edu.tw Recent emerging biochemical data indicate that several important neuroregulatory genes and
proteins may be involved in the etiology of schizophrenia and bipolar disorder. Additionally, the
same genes appear to be targets of several psychotropic medications that are used to ... Cited by 39 - Related articles - View as HTML - BL Direct - All 8 versions
- ►pubget.com [PDF] SC Elbein, WS Chu, SK Das, A Yao-Borengasser, SJ … - Diabetologia, 2007 - Springer Abstract Aims/hypothesis We sought to determine: (1) the role of previously described transcription
factor 7-like 2 (TCF7L2) variants in type 2 diabetes in African American individuals and in participants
of European ancestry; (2) the physio- logical impact of these variants on glucose ... Cited by 31 - Related articles - BL Direct - All 6 versions
- ►endojournals.org H Wang, Z Zhang, W Chu, T Hale, JJ Cooper, … - Journal of Clinical …, 2005 - Endocrine Soc IL-6 levels and polymorphisms have been implicated in type 2 diabetes mellitus (T2DM) and
insulin resistance. The IL-6 receptor (IL-6R) comprises two subunits, IL-6R and gp130, of which
IL-6R confers specificity to IL-6 action and is located in a region of replicated linkage to ... Cited by 28 - Related articles - All 5 versions
SK Das, SC Elbein - Cellscience, 2006 - pubmedcentral.nih.gov Type 2 Diabetes results from a complex physiologic process that includes the pancreatic beta
cells, peripheral glucose uptake in muscle, the secretion of multiple cytokines and hormone-like
molecules from adipocytes, hepatic glucose production, and likely the central nervous ... Cited by 25 - Related articles - All 3 versions
- ►diabetesjournals.org SK Das, W Chu, Z Zhang, SJ Hasstedt, SC Elbein - Diabetes, 2004 - Am Diabetes Assoc Genome-wide scans in multiple populations have identified chromosome 1q21-q24 as one susceptibility
region for type 2 diabetes. To map the susceptibility genes, we first placed a dense single nucleotide
polymorphism (SNP) map across the linked region. We identified two SNPs that showed ... Cited by 14 - Related articles - BL Direct - All 4 versions
SK Das, SC Elbein - Current Diabetes Reports, 2007 - Springer The unbiased approach of genome-wide linkage analysis has shown evidence for linkage of
type 2 diabetes mel- litus to the chromosome 1q21-25 region in at least eight independent
studies. More than 26 candidate genes have already been evaluated, but to date none ... Cited by 14 - Related articles - BL Direct - All 2 versions
H Wang, W Chu, SK Das, Z Zheng, SJ Hasstedt, SC … - Molecular Genetics and …, 2003 - Elsevier The retinoid-related orphan receptor γ (RORC) is a member of the nuclear hormone superfamily
which maps to the 1q21-q23 region. Linkage of type 2 diabetes (T2DM) to this region is well
replicated. Several factors argue that RORC is a strong candidate for T2DM susceptibility ... Cited by 13 - Related articles - All 4 versions
- ►diabetesjournals.org SK Das, WS Chu, TC Hale, X Wang, RL Craig, H Wang, … - Diabetes, 2006 - Am Diabetes Assoc Linkage of type 2 diabetes to chromosome 1q21-q23 is well replicated across populations. In
an initial 50-kb marker map (580 markers) across the linked region, one of the two strongest
associations observed in Utah Caucasians was at marker rs1503814 (P < 0.00001 in ... Cited by 12 - Related articles - BL Direct - All 6 versions
- ►diabetesjournals.org M Fu, CM Damcott, M Sabra, TI Pollin, SH Ott, J Wang, … - Diabetes, 2004 - Am Diabetes Assoc Calsequestrin (CASQ)1 is involved in intracellular storage and release of calcium, a process
that has been shown to mediate glucose transport in muscle. Its gene, CASQ1, is encoded on
chromosome 1q21, a region that has been linked to type 2 diabetes in the Amish and ... Cited by 12 - Related articles - BL Direct - All 5 versions
