R Hovorka - Diabetic medicine, 2006 - duke.edu Background The last two decades have witnessed unprecedented technological progress in
the development of continuous glucose sensors, resulting in the first generation of commercial
glucose monitors. This has fuelled the development of prototypes of a closed-loop system ... Cited by 116 - Related articles - View as HTML - BL Direct - All 7 versions
GM Steil, AE Panteleon, K Rebrin - Advanced drug delivery reviews, 2004 - Elsevier The development of an artificial pancreas for the treatment of insulin-dependent diabetes is a
highly desired endeavor for patients, physicians, scientists, and engineers. Historical algorithms
and recent progress in research and technology are reviewed in the present article, ... Cited by 95 - Related articles - All 4 versions
- ►physiology.org A Caumo, L Luzi - American Journal of Physiology- Endocrinology …, 2004 - Am Physiological Soc To fulfill its preeminent function of regulating glucose metabolism, insulin secretion must not
only be quantitatively appropriate but also have qualitative, dynamic properties that optimize
insulin action on target tissues. This review focuses on the importance of the first-phase ... Cited by 42 - Related articles - All 3 versions
JC Henquin, M Nenquin, P Stiernet, B Ahren - Diabetes, 2006 - Am Diabetes Assoc The mechanisms underlying biphasic insulin secretion have not been completely
elucidated. We compared the pattern of plasma insulin changes during hyperglycemic clamps
in mice to that of glucose-induced insulin secretion and cytosolic calcium concentration ... Cited by 36 - Related articles - BL Direct - All 5 versions
- ►psu.edu [PDF] J Li, Y Kuang, CC Mason - Journal of theoretical biology, 2006 - Elsevier In the glucose–insulin regulatory system, ultradian insulin secretory oscillations are observed
to have a period of 50–150 min. After pioneering work traced back to the 1960s, several mathematical
models have been proposed during the last decade to model these ultradian oscillations ... Cited by 25 - Related articles - All 8 versions
GM Steil, B Clark, S Kanderian, K Rebrin - Diabetes Technology & …, 2005 - liebertonline.com Three models of glucose homeostasis are compared in terms of their steady-state dose–re- sponse
characteristics, how they characterize glucose distribution kinetics, and how they char- acterize
the dynamics of insulin action. The three models [minimal model, AIDA (Automated ... Cited by 22 - Related articles - All 2 versions
- ►diabetes.org.br [PDF] E Arbit - Diabetes Technology & Therapeutics, 2004 - liebertonline.com Insulin remains the most effective and durable drug in the armamentarium for the treatment of
advanced-stage diabetes. Nevertheless, clinical studies have shown that even on insulin
treatment, a significant percentage of patients fail to attain lasting glycemic control. ... Cited by 20 - Related articles - BL Direct - All 5 versions
- ►canterbury.ac.nz [PDF] CV Doran, NH Hudson, KT Moorhead, JG Chase, … - Medical Engineering and …, 2004 - Elsevier Close control of blood glucose levels significantly reduces vascular complications in Type 1 and
Type 2 diabetic individuals. Heavy derivative controllers using the data density available from
emerging biosensors are developed to provide tight, optimal control of elevated blood ... Cited by 16 - Related articles - All 11 versions
GM Steil, K Rebrin - edd, 2005 - Informa Pharma Science Closed-loop insulin delivery in individuals with diabetes can potentially lead to near-normal glucose
profiles. To this end, existing subcutaneous glucose sensors and external insulin pumps can
be linked with an insulin delivery algorithm to create a completely automated closed-loop ... Cited by 14 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org J Girard - Diabetes, 2006 - Am Diabetes Assoc Previous studies suggest that insulin can inhibit hepatic glucose production by both direct and
indirect actions. The indirect effects include inhibition of glucagon secretion, reduction in plasma
nonesterified fatty acid levels, reduction of the amount of gluconeogenic precursor ... Cited by 11 - Related articles - BL Direct - All 5 versions
