- ►cell.com JE Gunton, RN Kulkarni, SH Yim, T Okada, WJ … - Cell, 2005 - Elsevier Type 2 diabetes is an epidemic disease affecting almost 200 million people
worldwide (Zimmet et al., 2001). The pathogenesis involves two core defects:
insulin resistance and impaired β cell function ([Martin et al., 1992], ... Cited by 115 - Related articles - All 14 versions
- ►endojournals.org P Marchetti, S Del Guerra, L Marselli, R Lupi, … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Several properties of pancreatic ß-cells in type 2 diabetes (T2D) were studied
by using islets isolated from T2D subjects. Moreover, because metformin has
protective effects on nondiabetic ß-cells exposed to high glucose or free ... Cited by 92 - Related articles - BL Direct - All 5 versions
JE Gerich - Mayo Clinic Proceedings, 2003 - mayoclinicproceedings.com From the Department of Medicine, University of Rochester School of Medicine and
Dentistry, Rochester, NY. Individual reprints of this article are not available.
Address corre- spondence to John E. Gerich, MD, Department of Medicine, ... Cited by 93 - Related articles - View as HTML - BL Direct - All 14 versions
- ►nih.gov X Jing, DQ Li, CS Olofsson, A Salehi, VV … - Journal of Clinical Investigation, 2005 - Am Soc Clin Investig Concerted activation of different voltage-gated Ca 2+ channel isoforms may
determine the kinetics of insulin release from pancreatic islets. Here we have
elucidated the role of R-type Ca V 2.3 channels in that process. A 20% ... Cited by 64 - Related articles - All 9 versions
- Free from Publisher C Meyer, W Pimenta, HJ Woerle, T Van Haeften … - Diabetes Care, 2006 - Am Diabetes Assoc RESULTS—Compared with NFG/NGT, IFG/NGT had similar fasting insulin
concentrations despite hyperglycemia; therefore, HOMA-IR was increased ∼30% (P
< 0.05), but clamp-determined insulin sensitivity was normal (P > 0.8). ... Cited by 66 - Related articles - BL Direct - All 5 versions
S Del Prato - Diabetologia, 2003 - Springer Aims/Hypothesis. A loss of early-phase insulin re- sponse is common in Type 2
diabetic patients and in people with impaired glucose metabolism. It is hy-
pothesized that this alteration is not simply a marker for the risk of ... Cited by 62 - Related articles - BL Direct - All 4 versions
W Wente, AM Efanov, M Brenner, A … - Diabetes, 2006 - Am Diabetes Assoc Fibroblast growth factor-21 (FGF-21) is a recently discovered metabolic
regulator. Here, we investigated the effects of FGF-21 in the pancreatic
β-cell. In rat islets and INS-1E cells, FGF-21 activated extracellular ... Cited by 56 - Related articles - BL Direct - All 4 versions
G Di Cianni, R Miccoli, L Volpe, C Lencioni, S … - Diabetes/Metabolism Reviews - interscience.wiley.com Complex though integrated hormonal and metabolic changes characterize pregnancy.
In the face of progressive decline in insulin action, glucose homeostasis is
maintained through a compensatory increase in insulin secretion. This ... Cited by 51 - Related articles - BL Direct - All 3 versions
- ►endojournals.org HJ Goren, RN Kulkarni, CR Kahn - Endocrinology, 2004 - Endocrine Soc Transgenic mice phenotypes generally depend on the background strains used in
their creation. To examine the effects of genetic background on insulin
signaling, we analyzed glucose homeostasis in four inbred strains of mice ... Cited by 49 - Related articles - BL Direct - All 5 versions
- ►ajcn.org DE Laaksonen, LK Toppinen, KS Juntunen, K … - American Journal of Clinical Nutrition, 2005 - Am Soc Nutrition Design: We assessed the effect of carbohydrate modification on insulin and
glucose metabolism in 72 overweight or obese men and women with the metabolic
syndrome, as determined according to the National Cholesterol Education ... Cited by 52 - Related articles - BL Direct - All 8 versions
