R Lupi, F Dotta, L Marselli, S Del Guerra, M … - Diabetes, 2002 - Am Diabetes Assoc In an effort to better understand the phenomenon of lipotoxicity in human
β-cells, we evaluated the effects of 48-h preculture with 1.0 or 2.0 mmol/l
free fatty acid (FFA) (2:1 oleate to palmitate) on the function and ... Cited by 270 - Related articles - BL Direct - All 7 versions
W El-Assaad, J Buteau, ML Peyot, C Nolan, R … - Endocrinology, 2003 - Endocrine Soc We have proposed the "glucolipotoxicity" hypothesis in which elevated free fatty
acids (FFAs) together with hyperglycemia are synergistic in causing islet
ß-cell damage because high glucose inhibits fat oxidation and consequently ... Cited by 174 - Related articles - BL Direct - All 5 versions
- ►nih.gov V Lyssenko, L Groop - Journal of Clinical Investigation, 2007 - Am Soc Clin Investig Genetic variants in the gene encoding for transcription factor-7–like 2
(TCF7L2) have been associated with type 2 diabetes (T2D) and impaired β cell
function, but the mechanisms have remained unknown. We therefore studied ... Cited by 136 - Related articles - BL Direct - All 13 versions
S Del Prato, P Marchetti, RC Bonadonna - Diabetes, 2002 - Am Diabetes Assoc Type 2 diabetes is a heterogeneous disorder due to prevalent insulin resistance
associated with deficient insulin secretion or to a prevalent defect of insulin
secretion associated with impaired insulin action. The definition is ... Cited by 126 - Related articles - BL Direct - All 5 versions
S Del Guerra, R Lupi, L Marselli, M Masini, M … - Diabetes, 2005 - Am Diabetes Assoc To shed further light on the primary alterations of insulin secretion in type 2
diabetes and the possible mechanisms involved, we studied several functional and
molecular properties of islets isolated from the pancreata of 13 type 2 ... Cited by 107 - Related articles - All 5 versions
- ►endojournals.org P Marchetti, S Del Guerra, L Marselli, R Lupi, … - Journal of Clinical Endocrinology & Metabolism, 2004 - Endocrine Soc Several properties of pancreatic ß-cells in type 2 diabetes (T2D) were studied
by using islets isolated from T2D subjects. Moreover, because metformin has
protective effects on nondiabetic ß-cells exposed to high glucose or free ... Cited by 92 - Related articles - BL Direct - All 5 versions
- ►physiology.org R Lupi, S Del Guerra, L Marselli, M Bugliani, … - American Journal of Physiology- Endocrinology And …, 2004 - Am Physiological Soc Peroxisome proliferator-activated receptors (PPARs) are a subgroup of the
superfamily of nuclear receptors, with three distinct main types: , and
(subdivided into 1 and 2 ). Recently, the presence of PPAR has been ... Cited by 79 - Related articles - BL Direct - All 4 versions
H Walter, G Lubben - Drugs, 2005 - ingentaconnect.com Worsening glycaemic control in type 2 diabetes mellitus relates to a decline in
Abstract β-cell function, associated with impaired negative feedback regulation
of insulin release. Insulin resistance, the 'traditional' cornerstone ... Cited by 59 - Related articles - All 5 versions
M Freemark - Journal of Clinical Endocrinology & Metabolism, 2003 - Endocrine Soc The past generation has witnessed a surge in the number of children,
adolescents, and young adults with type 2 diabetes (1, 2, 3). In most cases the
illness begins with excess weight gain, insulin resistance, and ... Cited by 38 - Related articles - BL Direct - All 5 versions
AH Lockwood - Diabetes Care, 2002 - Am Diabetes Assoc Data from the 2000 Behavioral Risk Factor Surveillance System (BRFSS) were used
to determine diabetes prevalence, by state (1). These data are based on
self-reports obtained from 184,450 randomly dialed participants. State ... Cited by 30 - Related articles - BL Direct - All 5 versions
