- ►uio.no [PDF] K Ohtsubo, S Takamatsu, MT Minowa, A Yoshida, M … - Cell, 2005 - Elsevier Pancreatic β cell-surface expression of glucose transporter 2 (Glut-2) is essential for
glucose-stimulated insulin secretion, thereby controlling blood glucose homeostasis in response
to dietary intake. We show that the murine GlcNAcT-IVa glycosyltransferase is required for ... Cited by 69 - Related articles - All 18 versions
D Kawamori, Y Kajimoto, H Kaneto, Y Umayahara, Y … - Diabetes, 2003 - Am Diabetes Assoc Oxidative stress is induced in pancreatic β-cells under diabetic conditions and causes β-cell
dysfunction. Antioxidant treatment of diabetic animals leads to recovery of insulin biosynthesis
and increases the expression of its controlling transcription factor, pancreatic duodenal ... Cited by 68 - Related articles - BL Direct - All 4 versions
- ►pubget.com [PDF] AA Toye, JD Lippiat, P Proks, K Shimomura, L Bentley, … - Diabetologia, 2005 - Springer Page 1. Diabetologia (2005) 48: 675–686 DOI 10.1007/s00125-005-1680-z ARTICLE AA Toye .
JD Lippiat . P. Proks . K. Shimomura . L.Bentley . A. Hugill . V. Mijat . M. Goldsworthy . L.Moir .
A. Haynes . J. Quarterman . HC Freeman . FM Ashcroft . RD Cox ... Cited by 57 - Related articles - All 4 versions
Y Lu, PL Herrera, Y Guo, D Sun, Z Tang, D LeRoith, JL … - Diabetes, 2004 - Am Diabetes Assoc The dogma that IGF-I stimulates pancreatic islet growth has been challenged by combinational
targeting of IGF or IGF-IR (IGF receptor) genes as well as β-cell–specific IGF-IR gene
deficiency, which caused no defect in islet cell growth. To assess the physiological role of ... Cited by 41 - Related articles - BL Direct - All 4 versions
- ►wisc.edu [PDF] SD Covey, RD Wideman, C McDonald, S Unniappan, F … - Cell Metabolism, 2006 - Elsevier The hormone leptin plays a crucial role in maintenance of body weight and glucose
homeostasis. This occurs through central and peripheral pathways, including regulation of insulin
secretion by pancreatic β cells. To study this further in mice, we disrupted the signaling ... Cited by 37 - Related articles - All 8 versions
- ►diabetesjournals.org J Roccisana, V Reddy, RC Vasavada, JA Gonzalez- … - Diabetes, 2005 - Am Diabetes Assoc Overexpression of hepatocyte growth factor (HGF) in the ß-cell of transgenic mice enhances
ß-cell proliferation, survival, and function. In the current studies, we have used conditional ablation
of the c-met gene to uncover the physiological role of HGF in ß-cell growth and function. ... Cited by 33 - Related articles - All 6 versions
- ►endojournals.org NS Sauter, FT Schulthess, R Galasso, LW Castellani, K … - Endocrinology, 2008 - Endocrine Soc Subclinical inflammation is a recently discovered phenomenon in type 2 diabetes. Elevated cytokines
impair β-cell function and survival. A recent clinical trial shows that blocking IL-1β signaling by
IL-1 receptor antagonist (IL-1Ra) improves β-cell secretory function in patients with type 2 ... Cited by 19 - Related articles - BL Direct - All 4 versions
M Fex, MD Nitert, N Wierup, F Sundler, C Ling, H … - Diabetologia, 2007 - Springer Abstract Aim/hypothesis Hyperinsulinaemia maintains euglycaemia in insulin-resistant
states. The precise cellular mechanisms by which the beta cells adapt are still unresolved. A
peripherally derived cue, such as increased circulating fatty acids, may instruct the beta ... Cited by 16 - Related articles - BL Direct - All 4 versions
JL Liu - Cell biochemistry and biophysics, 2007 - Springer Abstract Both IGF-I and its receptor (IGF-IR) are spe- cifically expressed in various cell types
of the endocrine pancreas. IGF-I has long been considered a growth factor for islet cells as it
induces DNA synthesis in a glucose- dependent manner, prevents Fas-mediated ... Cited by 6 - Related articles - BL Direct - All 5 versions
