JC Henquin, MA Ravier, M Nenquin, … - … Journal of Clinical …, 2003 - journals.indexcopernicus.com logo IndexCopernicus, Current language: English. IC Journals Master List. Journal of the Week.
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Publishers. Top 20 Publishers. Journal Search. Evaluation methodology. ... Cited by 79 - Related articles - BL Direct - All 4 versions
MA Ravier, M Güldenagel, A Charollais, A Gjinovci, D … - Diabetes, 2005 - Am Diabetes Assoc Normal insulin secretion requires the coordinated functioning of β-cells within pancreatic
islets. This coordination depends on a communications network that involves the interaction
of β-cells with extracellular signals and neighboring cells. In particular, adjacent β-cells ... Cited by 60 - Related articles - All 4 versions
- ►physiology.org MJ MacDonald, LA Fahien, LJ Brown, NM … - American Journal of …, 2005 - Am Physiological Soc The importance of mitochondrial biosynthesis in stimulus secretion coupling in the insulin-producing
-cell probably equals that of ATP production. In glucose-induced insulin secretion, the rate of
pyruvate carboxylation is very high and correlates more strongly with the glucose ... Cited by 60 - Related articles - All 4 versions
- ►physiology.org LE Fridlyand, N Tamarina, LH … - American Journal of …, 2003 - Am Physiological Soc We have developed a detailed mathematical model of ionic flux in -cells that includes the most
essential channels and pumps in the plasma membrane. This model is coupled to equations
describing Ca 2+ , inositol 1,4,5-trisphosphate (IP 3 ), ATP, and Na + homeostasis, ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org JC Henquin - Diabetes, 2004 - Am Diabetes Assoc Physiologically, insulin secretion is subject to a dual, hierarchal control by triggering and amplifying
pathways. By closing ATP-sensitive K + channels (K ATP channels) in the plasma
membrane, glucose and other metabolized nutrients depolarize β-cells, stimulate Ca 2+ ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►nih.gov PO Westermark, A Lansner - Biophysical Journal, 2003 - Elsevier We have constructed a model of the upper part of the glycolysis in the pancreatic β-cell. The
model comprises the enzymatic reactions from glucokinase to glyceraldehyde-3-phosphate dehydrogenase
(GAPD). Our results show, for a substantial part of the parameter space, an oscillatory ... Cited by 33 - Related articles - BL Direct - All 11 versions
- ►nih.gov MG Pedersen, R Bertram, A Sherman - Biophysical journal, 2005 - Elsevier Insulin secretion from pancreatic β-cells is pulsatile with a period of 5–10 min and is believed
to be responsible for plasma insulin oscillations with similar frequency. To observe an overall
oscillatory insulin profile it is necessary that the insulin secretion from individual β-cells is ... Cited by 31 - Related articles - BL Direct - All 14 versions
M Düfer, D Haspel, P Krippeit-Drews, L Aguilar-Bryan, … - Diabetologia, 2004 - Springer Aims/hypothesis. SUR1(ABCC8) −/− mice lacking func- tional KATP channels are an appropriate
model to test the significance of KATP channels in beta-cell function. We examined how this
gene deletion interferes with stimulus-secretion coupling. We tested the influence of ... Cited by 26 - Related articles - BL Direct - All 4 versions
CS Nunemaker, M Zhang, DH Wasserman, OP … - Diabetes, 2005 - Am Diabetes Assoc Pulsatile insulin secretion in vivo is believed to be derived, in part, from the intrinsic
glucose-dependent intracellular calcium concentration ([Ca 2+ ] i ) pulsatility of individual
islets. In isolation, islets display fast, slow, or mixtures of fast and slow [Ca 2+ ] i ... Cited by 24 - Related articles - BL Direct - All 10 versions
- ►psu.edu [PDF] J Li, Y Kuang, CC Mason - Journal of theoretical biology, 2006 - Elsevier In the glucose–insulin regulatory system, ultradian insulin secretory oscillations are observed
to have a period of 50–150 min. After pioneering work traced back to the 1960s, several mathematical
models have been proposed during the last decade to model these ultradian oscillations ... Cited by 25 - Related articles - All 8 versions
