- ►nih.gov [PDF] G da Silva Xavier, I Leclerc, A Varadi, T … - Biochemical …, 2003 - pubmedcentral.nih.gov AMP-activated protein kinase (AMPK) has recently been impli- cated in the control of preproinsulin
gene expression in pancreatic islet β-cells [da Silva Xavier, Leclerc, Salt, Doiron, Hardie, Kahn
and Rutter (2000) Proc. Natl. Acad. Sci. USA 97, 4023–4028]. Using pharmacological and ... Cited by 146 - Related articles - BL Direct - All 9 versions
- ►nih.gov R Bertram, L Satin, M Zhang, P Smolen, A Sherman - Biophysical journal, 2004 - Elsevier Pancreatic islets of Langerhans produce bursts of electrical activity when exposed to stimulatory
glucose levels. These bursts often have a regular repeating pattern, with a period of 10–60
s. In some cases, however, the bursts are episodic, clustered into bursts of bursts, which ... Cited by 46 - Related articles - BL Direct - All 15 versions
- ►physiology.org LE Fridlyand, N Tamarina, LH … - American Journal of …, 2003 - Am Physiological Soc We have developed a detailed mathematical model of ionic flux in -cells that includes the most
essential channels and pumps in the plasma membrane. This model is coupled to equations
describing Ca 2+ , inositol 1,4,5-trisphosphate (IP 3 ), ATP, and Na + homeostasis, ... Cited by 37 - Related articles - BL Direct - All 4 versions
- ►psu.edu [PDF] R Bertram, A Sherman - Bulletin of mathematical biology, 2004 - Springer Insulin-secreting β-cells, located within the pancreatic islets of Langerhans, are excitable cells
that produce regular bursts of action potentials when stimulated by glucose. This system has
been the focus of mathematical investigation for two decades, spawning an array of ... Cited by 34 - Related articles - All 6 versions
- ►endojournals.org SN Yang, PO Berggren - Endocrine reviews, 2006 - Endocrine Soc Voltage-gated calcium (Ca V ) channels are ubiquitously expressed in various cell types throughout
the body. In principle, the molecular identity, biophysical profile, and pharmacological property
of Ca V channels are independent of the cell type where they reside, whereas these ... Cited by 34 - Related articles - BL Direct - All 6 versions
D Burdakov, SM Luckman, A … - … Transactions of the …, 2005 - rstb.royalsocietypublishing.org Specialized subgroups of hypothalamic neurons exhibit specific excitatory or inhibitory electrical
responses to changes in extracellular levels of glucose. Glucose-excited neurons were traditionally
assumed to employ a 'β-cell' glucose-sensing strategy, where glucose elevates cytosolic ... Cited by 33 - Related articles - BL Direct - All 13 versions
DS Luciani, S Misler, KS Polonsky - The Journal of Physiology, 2006 - Physiological Soc Exposure of pancreatic islets of Langerhans to physiological concentrations of glucose leads
to secretion of insulin in an oscillatory pattern. The oscillations in insulin secretion are associated
with oscillations in cytosolic Ca 2+ concentration ([Ca 2+ ] c ). Evidence suggests that the ... Cited by 26 - Related articles - BL Direct - All 7 versions
GA Rutter, T Tsuboi, MA Ravier - Cell Calcium, 2006 - Elsevier Nutrient-induced increases in intracellular free Ca 2+ concentrations are the key trigger for insulin
release from pancreatic islet β-cells. These Ca 2+ changes are tightly regulated temporally, occurring
as Ca 2+ influx-dependent baseline oscillations. We explore here the concept that locally ... Cited by 22 - Related articles - All 4 versions
- ►endocrinology-journals.org W Wang, L Upshaw, DM Strong, RP … - Journal of …, 2005 - Soc Endocrinology In this study, we investigated the use of a novel oxygen biosensor system to detect changes in
oxygen consumption rates (OCRs) by islets in response to glucose. Islets from non-human primate
and human pancreata were seeded into an oxygen biosensor system microplate and ... Cited by 22 - Related articles - All 3 versions
A Salehi, SS Qader, E Grapengiesser, B Hellman - Diabetes, 2005 - Am Diabetes Assoc External ATP has been proposed to be an autocrine regulator of glucose-stimulated insulin secretion
and responsible for the synchronization of the Ca 2+ rhythmicity in the β-cells required for a pulsatile
release of insulin from the pancreas. The importance of external ATP for ... Cited by 19 - Related articles - All 5 versions
