MA Ravier, M Güldenagel, A Charollais, A Gjinovci, D … - Diabetes, 2005 - Am Diabetes Assoc Normal insulin secretion requires the coordinated functioning of β-cells within pancreatic
islets. This coordination depends on a communications network that involves the interaction
of β-cells with extracellular signals and neighboring cells. In particular, adjacent β-cells ... Cited by 60 - Related articles - All 4 versions
- ►nih.gov [PDF] TA Kinard, G De Vries, A Sherman, LS Satin - Biophysical journal, 1999 - Elsevier Glucose triggers bursting activity in pancreatic islets, which mediates the Ca 2+ uptake that triggers
insulin secretion. Aside from the channel mechanism responsible for bursting, which remains
unsettled, it is not clear whether bursting is an endogenous property of individual β-cells ... Cited by 58 - Related articles - BL Direct - All 12 versions
P Gilon, MA Ravier, JC Jonas, JC Henquin - Diabetes, 2002 - Am Diabetes Assoc The mechanisms driving the pulsatility of insulin secretion in vivo and in vitro are still
unclear. Because glucose metabolism and changes in cytosolic free Ca 2+ ([Ca 2+ ] c ) in β-cells
play a key role in the control of insulin secretion, and because oscillations of these two ... Cited by 50 - Related articles - BL Direct - All 5 versions
M Düfer, D Haspel, P Krippeit-Drews, L Aguilar-Bryan, … - Diabetologia, 2004 - Springer Aims/hypothesis. SUR1(ABCC8) −/− mice lacking func- tional KATP channels are an appropriate
model to test the significance of KATP channels in beta-cell function. We examined how this
gene deletion interferes with stimulus-secretion coupling. We tested the influence of ... Cited by 26 - Related articles - BL Direct - All 4 versions
- ►aspetjournals.org G Liu, N Hilliard, GH Hockerman - Molecular pharmacology, 2004 - ASPET The link between Ca 2+ influx through the L-type calcium channels Ca v 1.2 or Ca v 1.3 and
glucose- or KCl-induced [Ca 2+ ] i mobilization in INS-1 cells was assessed using the calcium
indicator indo-1. Cells responded to 18 mM glucose or 50 mM KCl stimulation with ... Cited by 13 - Related articles - BL Direct - All 5 versions
MA Ravier, M Guldenagel, A Charollais, A Gjinovci, D … - Diabetes, 2005 - Am Diabetes Assoc Normal insulin secretion requires the coordinated func- tioning of -cells within pancreatic
islets. This coordi- nation depends on a communications network that involves the interaction
of -cells with extracellular signals and neighboring cells. In particular, adjacent -cells are ... Cited by 11 - Related articles - All 2 versions
F Diederichs - Bulletin of mathematical biology, 2006 - Springer Abstract A new type of equation to describe enzyme-catalyzed reactions was de- veloped, which
allows the description of processes both at or near equilibrium and far from equilibrium, as they
are both known to occur in the living cell. These equations combine kinetic as well as ... Cited by 7 - Related articles - All 4 versions
- ►nih.gov I Novak - Purinergic Signalling, 2008 - Springer Abstract The pancreas is a complex gland performing both endocrine and exocrine
functions. In recent years there has been increasing evidence that both endocrine and exocrine
cells possess purinergic receptors, which influence processes such as insulin secretion ... Cited by 8 - Related articles - All 4 versions
JC Henquin - Diabetologia, 2009 - Springer Abstract The consensus model of stimulus–secretion coupling in beta cells attributes
glucose-induced insulin secretion to a sequence of events involving acceleration of
metabolism, closure of ATP-sensitive K + channels, depo- larisation, influx of Ca 2+ and a ... Cited by 7 - Related articles - All 3 versions
- ►cell.com M Zhang, B Fendler, B Peercy, P Goel, R Bertram, A … - Biophysical Journal, 2008 - Elsevier Individual mouse pancreatic islets exhibit oscillations in [Ca 2+ ] i and insulin secretion in response
to glucose in vitro, but how the oscillations of a million islets are coordinated within the human
pancreas in vivo is unclear. Islet to islet synchronization is necessary, however, for the ... Cited by 1 - Related articles - All 8 versions
