- ►physiology.org S Seino, T Shibasaki - Physiological reviews, 2005 - Am Physiological Soc Stimulus-secretion coupling is an essential process in secretory cells in which regulated exocytosis
occurs, including neuronal, neuroendocrine, endocrine, and exocrine cells. While an increase in
intracellular Ca 2+ concentration ... Cited by 146 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org GG Holz - Diabetes, 2004 - Am Diabetes Assoc Recently published studies of islet cell function reveal unexpected features of glucagon-like
peptide-1 (GLP-1) receptor-mediated signal transduction in the pancreatic β-cell. Although GLP-1 is
established to be a cAMP-elevating ... Cited by 127 - Related articles - BL Direct - All 6 versions
PE MacDonald, W El-kholy, MJ Riedel, AMF Salapatek, … - Diabetes, 2002 - Am Diabetes Assoc The physiological effects of glucagon-like peptide-1 (GLP-1) are of immense interest because of the
potential clinical relevance of this peptide. Produced in intestinal L-cells through
posttranslational processing of the ... Cited by 95 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org CB Chan, MC Saleh, V Koshkin, MB Wheeler - Diabetes, 2004 - Am Diabetes Assoc Stressors such as chronic hyperglycemia or hyperlipidemia may lead to insufficient insulin secretion
in susceptible individuals, contributing to type 2 diabetes. The molecules mediating this effect are
just beginning to be identified. ... Cited by 84 - Related articles - BL Direct - All 4 versions
- ►rupress.org N Takahashi, H Hatakeyama, H Okado, A Miwa, T … - Journal of Cell …, 2004 - jcb.rupress.org We have investigated sequential exocytosis in ß cells of intact pancreatic islets with the use of
two-photon excitation imaging of a polar fluorescent tracer, sulforhodamine B, and a fusion protein
comprising enhanced cyan ... Cited by 44 - Related articles - BL Direct - All 10 versions
- ►physoc.org G Kang, GG Holz - The Journal of Physiology, 2003 - Physiological Soc Functional coupling between Ca 2+ -induced Ca 2+ release (CICR) and quantal exocytosis in
5-hydroxytryptamine-loaded INS-1 β cells was assessed through the use of carbon fibre amperometry
in combination with Fura-2. CICR ... Cited by 38 - Related articles - BL Direct - All 16 versions
L Chen, DS Koh, B Hille - Diabetes, 2003 - Am Diabetes Assoc Pancreatic β-cells maintain glucose homeostasis by their regulated Ca 2+ -dependent secretion of
insulin. Several cellular mechanisms control intracellular Ca 2+ levels, but their relative
significance in mouse β-cells is ... Cited by 31 - Related articles - BL Direct - All 5 versions
H Hatakeyama, T Kishimoto, T Nemoto, H … - The Journal of …, 2006 - Physiological Soc The role of protein kinase A (PKA) in insulin exocytosis was investigated with the use of two-photon
excitation imaging of mouse islets of Langerhans. Inhibitors of PKA selectively reduced the number
of exocytic events during the ... Cited by 14 - Related articles - BL Direct - All 12 versions
- ►endojournals.org J Li, KL O'Connor, X Cheng, FC Mei, T Uchida, … - Molecular …, 2007 - Endocrine Soc Neurotensin (NT), a gut peptide, plays important roles in gastrointestinal secretion, inflammation,
and growth of normal and neoplastic tissues. cAMP regulates the secretion of hormones via its
effector proteins protein kinase A ... Cited by 10 - Related articles - BL Direct - All 4 versions
- ►eje-online.org P Thams, MR Anwar, K Capito - European Journal of Endocrinology, 2005 - EFES Results: In islets cultured at 5.5 mmol/l glucose, and then perifused in physiological
Krebs–Ringer medium, the PKA inhibitors, H89 (10 µmol/l) and PKI 6–22 amide (30 µmol/l) did
not inhibit glucose (16.7 mmol/l)- ... Cited by 6 - Related articles - All 7 versions
