- ►endojournals.org A Mari, WM Sallas, YL He, C Watson, M … - Journal of Clinical …, 2005 - Endocrine Soc Results: Vildagliptin significantly increased the insulin secretory rate at 7 mmol/liter glucose
(secretory tone), calculated from the dose response; the difference in least squares mean (
LSM) was 101 ± 51 pmol·min –1 ·m –2 (P = 0.002). The slope of the ß-cell dose response, ... Cited by 198 - Related articles - BL Direct - All 8 versions
- ►endojournals.org E Ferrannini, A Gastaldelli, Y Miyazaki, M … - Journal of Clinical …, 2005 - Endocrine Soc The nature of the progressive ß-cell failure occurring as normal glucose tolerant (NGT) individuals
progress to type 2 diabetes (T2DM) is incompletely understood. We measured insulin sensitivity
(by a euglycemic insulin clamp) and insulin secretion rate (by deconvolution of plasma C- ... Cited by 133 - Related articles - All 5 versions
GM Steil, AE Panteleon, K Rebrin - Advanced drug delivery reviews, 2004 - Elsevier The development of an artificial pancreas for the treatment of insulin-dependent diabetes is a
highly desired endeavor for patients, physicians, scientists, and engineers. Historical algorithms
and recent progress in research and technology are reviewed in the present article, ... Cited by 95 - Related articles - All 4 versions
- ►physiology.org A Mari, O Schmitz, A Gastaldelli, T … - American Journal of …, 2002 - Am Physiological Soc We investigated -cell function and its relationship to insulin sensitivity in 17 normal
volunteers. For insulin secretion (derived by C-peptide deconvolution), a mathematical model
was applied to 24-h triple-meal tests (MT) as well as oral glucose tolerance tests (OGTT); ... Cited by 89 - Related articles - BL Direct - All 5 versions
G Pacini, A Mari - Best Practice & Research Clinical Endocrinology & …, 2003 - Elsevier The quantitative assessment of insulin sensitivity (IS) and β-cell function (BCF) is fundamental
in the study of metabolic disorders. The most relevant experimental tests and data analysis methods
for assessing both IS and BCF are described and their characteristic features discussed. ... Cited by 86 - Related articles - All 6 versions
- ►ahajournals.org AM Sironi, A Gastaldelli, A Mari, D Ciociaro, V Postano, … - Hypertension, 2004 - Am Heart Assoc Preferential visceral adipose tissue (VAT) deposition has been associated with the presence
of insulin resistance in obese and diabetic subjects. The independent association of VAT accumulation
with hypertension and its impact on insulin sensitivity and ß-cell function have not been ... Cited by 80 - Related articles - BL Direct - All 5 versions
E Ferrannini, A Mari - Diabetologia, 2004 - Springer The importance of both insulin resistance and beta cell dysfunction in the pathogenesis of glucose
intolerance is widely recognised. Also popular is the concept that beta cell secretory function
must be viewed in the context of extant insulin resistance. This For Debate moves from ... Cited by 76 - Related articles - BL Direct - All 4 versions
- ►diabetesjournals.org C Guidone, M Manco, E Valera-Mora, A Iaconelli, D … - Diabetes, 2006 - Am Diabetes Assoc Currently, there are no data in the literature regarding the pathophysiological mechanisms involved
in the rapid resolution of type 2 diabetes after bariatric surgery, which was reported as an additional
benefit of the surgical treatment for morbid obesity. With this question in mind, insulin ... Cited by 73 - Related articles - BL Direct - All 5 versions
- ►endojournals.org B Balas, MR Baig, C Watson, BE Dunning, M … - Journal of Clinical …, 2007 - Endocrine Soc Results: After vildagliptin, suppression of endogenous glucose production (EGP) during 6-h MTT
was greater than with placebo (1.02 ± 0.06 vs. 0.74 ± 0.06 mg·kg –1 ·min –1 ; P = 0.004), and
insulin secretion rate increased by 21% (P = 0.003) despite significant reduction in mean ... Cited by 67 - Related articles - BL Direct - All 5 versions
E Ferrannini, A Gastaldelli, Y Miyazaki, M Matsuda, M … - Diabetologia, 2003 - Springer Aims/hypothesis. Impaired glucose tolerance (IGT) is an insulin-resistant state and a risk factor
for Type 2 diabetes. The relative roles of insulin resistance and insulin deficiency in IGT have
been disputed. Methods. In 40 IGT subjects and 63 sex-, age-, and weight-matched ... Cited by 60 - Related articles - BL Direct - All 3 versions
